Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Prevalence, predictors, and moderators of transfer in primary care. [PDF]
Murphy BN +8 more
europepmc +1 more source
Molecular-dynamics studies on the shock-induced phase transition of a
Kazume Nishidate +3 more
openalex +2 more sources
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Diffusional dynamic process of irreversible ferroelectric to antiferroelectric phase transition and the rate limit. [PDF]
Ge M +12 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Defining the population of adolescents in need of comprehensive transitional care based on diagnosis, visit frequency, and disease complexity. [PDF]
Henningsen MB +12 more
europepmc +1 more source
Localization and its impact on achieving SDGs and transitioning to post-SDGs in Indonesia
Andi Besse Rimba, Ichiro Sato, Kei Endo
openalex +1 more source
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Whispering gallery mode study of phase transition and shape change in liquid crystal droplets.
Neogi A +3 more
europepmc +1 more source

