Results 61 to 70 of about 419,180 (314)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Coal Seam Thickness Prediction Based on Transition Probability of Structural Elements

Applied Sciences, 2019
Coal seam thickness prediction is crucial in coal mine design and coal mining. In order to improve the prediction accuracy, an improved Kriging interpolation method on the basis of efficient data and Radial Basis Function (RBF-Kriging) is firstly ...
Ailing Qi, Wenhui Kang, Guangming Zhang, Haijun Lei   +3 more
doaj   +1 more source

Coherent and incoherent superposition of transition matrix elements of the squeezing operator

New Journal of Physics, 2022
We discuss the general matrix elements of the squeezing operator between number eigenstates of a harmonic oscillator (which may also represent a quantized mode of the electromagnetic radiation).
Sándor Varró
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Probabilistic approach of state transition elements of truss structures at corrosion [PDF]

E3S Web of Conferences
The purpose of the presented study is to determine and mathematically model the reliability of a steel truss with different variants of local failures of rod elements due to corrosion processes.
Matseevich Tatiana A., Dankov Saveliy A.
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Preparation and Characterization of Schiff Base Ligand (E)-2-(2-Oxoindolin-3-Ylidene) Hydrazine-1- Carbothioamide and its MetalComplexes with Study of Their Impact on the Division of Lymphocyte Cellsof Humans

Academic Science Journal
This research involved the synthesis of the ligand (E)-2-(2-oxoindolin-3-ylidene) hydrazinecarbothioamide (LM) from the reaction of indoline 2, 3-dione with thiosemicarbazide and characterization using 1HNMR, Uv-Vis, FT-IR, spectroscopy in addition to ...
AREEJ ALI, Teeba Khalid Adnan, Khansa Yousif Ahmed   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source