Results 121 to 130 of about 480,286 (292)

Genetic control of morphological transitions in a coacervating protein template

Soft Matter
Point mutations and thermal energy enable control over the assembly of a thermoresponsive silica-binding elastin-like polypeptide, while MD simulations and silicification reveal how the soft template transitions from micelle to proteinosome.
William C. Wixson, Nada Y. Naser, Aditya Sonpal, Jim Pfaendtner, François Baneyx   +4 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Clinical genetics and public policies: how should rare diseases be managed?

Clinical and Biomedical Research, 2014
The implementation of a specific policy for rare diseases in the Brazilian Unified Health System presents challenges in terms of its rationale. Recognizing the importance of rarity in the context of public health means understanding genetics as one of ...
Ida Schwartz, Monica Souza, Paulo Leivas, Lavinia Schuler-Faccini   +3 more
doaj   +2 more sources

Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography

Life Science Alliance
Cryo-electron tomography and subtomogram averaging reveal new structural features at the base of the light-sensing cilia of retinal rods, including the basal body, the Y-links between axoneme and membrane, and the ciliary necklace of the transition zone.
Zhixian Zhang, Abigail R Moye, Feng He, Muyuan Chen, Melina A Agosto, Theodore G Wensel   +5 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Genetic determinants of the flower color transition trait in autotetraploid rose populations

Scientia Horticulturae
Some roses exhibit a unique phenotype that we call flower color transition. Roses that have this phenotype have flowers with petals that transition from a light yellow to a dark pink/red color as the flower ages.
Haramrit Gill, Jeekin Lau, Luke Whiteley, Qiuyi Fu, David H. Byrne, Patricia E. Klein, Oscar Riera-Lizarazu   +6 more
doaj   +1 more source

Simulation of Ultrafast Optical Transitions using Genetic Algorithm

Nonlinear Analysis: Modelling and Control, 2001
The purpose of this paper is to investigate the possibility of application of the genetic algorithm to quantum control of electronic transitions between energy bands in solids. In particular, the hole transitions between valence bands induced by ultrashort (femtosecond duration) electric field pulse will be considered.
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Average fold-change of genetic pathways in biological transitions

Computers in Biology and Medicine
A biological transition from a state N to a state T is characterized by a rearrangement of the gene expression profile in the system, quantitatively measured through the differential expression of genes. In contrast, changes in genetic pathways are usually evaluated by means of hypothesis testing schemes. We introduce a quantitative measure in order to
Sandra Costa, Joan Nieves, Augusto Gonzalez   +2 more
openaire   +3 more sources