Results 201 to 210 of about 480,286 (292)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Transition From Children's to Adults' Healthcare for Youth With (Genetic) Intellectual Disabilities: An ERN-ITHACA Guideline. [PDF]

J Intellect Disabil Res
Klein Haneveld MJ, Świeczkowska K, Grybek T, Labunets K, van Amelsvoort TAMJ, Bedeschi MF, Behan C, Dufke A, Dupont J, Gaasterland CMW, Garavelli L, Helverschou SB, McAnallen S, Milska-Musa KA, van Staa A, Streață I, Stumpel CTRM, Tamburrino F, Vasseghi M, Vyshka K, Wierzba JM, ERN‐ITHACA Guideline Working Group, van Eeghen AM.   +22 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Behavioural phase transitions in the migratory locust, <i>Locusta migratoria</i>, are related to changes in the gut bacterial composition. [PDF]

ISME Commun
Kim J, Murakami T, Toyoda A, Mori H.
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Correction: Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study.

J Med Internet Res
Leaning IE, Costanzo A, Jagesar R, Reus LM, Visser PJ, Kas MJH, Beckmann CF, Ruhé HG, Marquand AF.   +8 more
europepmc   +1 more source

Improving Lifelong Comprehensive Care Coordination in Nephropathic Cystinosis: Multidisciplinary Perspectives. [PDF]

Kidney Int Rep
Golestaneh L, Ames EG, Doyle MH, Ghossein C, Grimm PC, Hewlett JL, Lim A, Marzinelli LS, Schmidt KJ, Smeryage B, Zaritsky JJ, Kaskel FJ.   +11 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Coordinating mRNA maturation: The U1 relay model. [PDF]

Mol Cell
Yoon Y, Quan C, Soles LV, Shi Y.
europepmc   +1 more source

Reassessing the mitochondrial DNA evidence for migration at the Mesolithic–Neolithic transition [PDF]

, 2008
Bonsall, Clive, Pickard, Benjamin, Pickard, Catriona   +2 more
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