Results 211 to 220 of about 1,054,375 (301)

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

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Transitional Cell Carcinoma

2012
semanticscholar   +3 more sources

Transitional cell carcinoma.

American Journal of Roentgenology, 1993
contrast-enhanced CTscanshowed themasswaswithinthecollecting system (Fig.1B).Thebladder andure-terwerenormal, andresultsofcytologic examination oftheurinewerenormal. Afternephroureterectomy, abulky,ses-sile,papillary tumor arising fromtheuroepithelium wasfoundintheupperpole.Microscopy revealed focalinvasionoftherenalparenchyma, andthefinalpathologic ...
M H, Lev, F S, Chew
openaire   +2 more sources

A transitional cell carcinoma cell line

In Vitro, 1978
A transitional cell carcinoma cell line, COLO 232, was derived from a primary urinary bladder tumor in a Caucasian male. In culture, COLO 232 retained distinct uroepithelial phenotypic traits and produced both carcinoembryonic antigen and adrenocorticotropic hormone. COLO 232 had a chromosome mode of 58 and retained the X and Y chromosomes.
G E, Moore, R T, Morgan, L A, Quinn, L K, Woods   +3 more
openaire   +2 more sources

Upper-tract transitional cell carcinoma

Urology, 1997
Advances in ureteroscopic techniques have made it possible to treat many upper-tract tumors conservatively. Such treatment has demonstrated acceptable survival and renal preservation in high-risk patients, particularly those with a solitary kidney, bilateral tumors, poor renal function, or prohibitive operative risk.
E R, Tawfiek, D H, Bagley
openaire   +2 more sources

Parafallopian Tube Transitional Cell Carcinoma

Gynecologic Oncology, 2002
Transitional cell carcinoma (TCC) has recently been acknowledged as a distinct histologic pattern of the uncommon primary fallopian tube carcinoma. However, rare cases of TCC that are closely associated to the extraluminal portion of the tube remain widely unrecognized.We present a left adnexal high-grade TCC in a 56-year-old postmenopausal woman with ...
Gladell P, Paner, Miguel, Gonzalez, Hytham, Al-Masri, Donna Marie, Smith, Aliya N, Husain   +4 more
openaire   +2 more sources

Zosteriform metastatic transitional cell carcinoma

International Journal of Dermatology, 2004
Presentation of metastatic nodules in a dermatomal distribution is very rare. We present the case of a 63‐year‐old woman with zosteriform metastasis secondary to transitional cell carcinoma of the bladder. Possible mechanisms of dissemination are discussed.
Christy A, Woodruff, Mojghan, Amrikachi, Sylvia, Hsu   +2 more
openaire   +2 more sources

Genetics of transitional cell carcinoma

Seminars in Surgical Oncology, 1992
AbstractSeveral models of genetic events which define the origin and progression of human tumors have been elucidated over the last several years. These models suggest that the study of tumors at the level of both the chromosome and the gene can be useful in elucidating molecular events in tumor progression and in determining the biologic behavior of ...
E A, Klein, R S, Chaganti
openaire   +2 more sources