Results 21 to 30 of about 2,248 (223)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Shunt active filter for power quality improvement [PDF]
, 2001 This paper describes the development of a low cost shunt active power filter with digital control, which allows dynamic power factor correction and both harmonics and zero-sequence current compensation.
Afonso, João L. +3 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Rural Facility Electric Power Quality Enhancement [PDF]
, 1991 Electric power disturbances are known to be more prevalent in small, isolated power systems than in larger interconnected grids which service most of the United States. This fact has given rise to a growing concern about the relative merits of different
Aspnes, J.D. +3 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Virtual reality applied to a full simulator of electrical sub-stations [PDF]
, 2008 This paper presents an application designed to train electrical sub-station operators by means of a virtual reality environment. The application allows full viewing of any of the sub-stations in the power supply network.
A. Carretero +17 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Modelling the Interoperability and the Use of Control Equipment in Electrical Substations [PDF]
, 2010 Simulators can be defined as information systems which reliably reproduce specific phenomena and they are mainly used in training, although their field of application has grown to include manufacturing and medicine among others. In electrical engineering,
Félez Mindán, Jesús +3 more
core +1 more source
World city network research at a theoretical impasse::On the need to re-establish qualitative approaches to understanding agency in world city networks [PDF]
, 2014 From the late 1990s, the establishment of a new relational ‘turn’ in the study of world city connectedness in globalization has run parallel to the wider relational turn occurring in economic geography.
Beaverstock, Jonathan V, Watson, Allan
core +3 more sources