FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Methods for Cryo-EM Single Particle Reconstruction of Macromolecules Having Continuous Heterogeneity. [PDF]
J Mol Biol, 2023 Toader B, Sigworth FJ, Lederman RR.
europepmc +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Synthetic Data-Driven Exoskeleton Control via Contralateral Gait Fusion for Variable-Speed Walking. [PDF]
Biomimetics (Basel)Shi J, Zhu H, Yang Y, Liu B, Wang X.
europepmc +1 more source
Assessment technologies of rail systems' structural adequacy - A review from mechanical engineering perspectives. [PDF]
Sci Prog, 2022 Hua X, Zatar W, Gadedesi A, Liao Z.
europepmc +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Rotor angle stability of a microgrid generator through polynomial approximation based on RFID data collection and deep learning. [PDF]
Sci RepKhan W +5 more
europepmc +1 more source
The Portiloop: A deep learning-based open science tool for closed-loop brain stimulation. [PDF]
PLoS One, 2022 Valenchon N +6 more
europepmc +1 more source