Results 181 to 190 of about 363,457 (364)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
LNG vessels transits through Suez Canal under the changing geopolitical context
Journal of Shipping and TradeThe aim of this paper is to investigate the impact of geopolitical events to the LNG transits through the Suez Canal. This paper examines the effects of the Russian invasion to Ukraine, and the following EU measures referring to energy independence from ...
Dionysios Polemis, Christos Bentsos
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Study on the Nonlinear Vibration Characteristic of Bending-torsional Coupled Single-stage Gear
Jixie chuandong, 2019 Taking spur gear pair as the research object, a 6-DOF coupled bending-torsion nonlinear vibration model including time-varying meshing stiffness, comprehensive error, backlash and input torque is established. Based on the bifurcation diagram and Poincare
Rongju Liu +3 more
doaj
Stable water isotopes and tritium tracers tell the same tale: no evidence for underestimation of catchment transit times inferred by stable isotopes in StorAge Selection (SAS)-function models [PDF]
, 2023 Siyuan Wang +3 more
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Fast dynamics and high effective dimensionality of liquid fluidity. [PDF]
Sci Rep, 2023 Cockrell C +4 more
europepmc +1 more source