Results 211 to 220 of about 363,457 (364)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Transitions

Family Medicine, 2022
openaire   +4 more sources

Concise network models of memory dynamics reveal explainable patterns in path data. [PDF]

Sci Adv
Sahasrabuddhe R, Lambiotte R, Rosvall M.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A young progenitor for the most common planetary systems in the Galaxy. [PDF]

Nature
Livingston JH, Petigura EA, David TJ, Masuda K, Owen J, Nesvorný D, Batygin K, de Leon J, Mori M, Ikuta K, Fukui A, Watanabe N, Orell Miquel J, Murgas F, Parviainen H, Korth J, Libotte F, Abreu García N, Gallardo PPM, Narita N, Pallé E, Tamura M, Yonehara A, Ridden-Harper A, Bieryla A, Trani AA, Mamajek EE, Ciardi DR, Gorjian V, Hillenbrand LA, Rebull LM, Newton ER, Mann AW, Vanderburg A, Stefánsson G, Mahadevan S, Cañas C, Ninan J, Higuera J, Todorov K, Désert JM, Pino L.   +41 more
europepmc   +1 more source

Transit Investments for Greenhouse Gas and Energy Reduction Program: Second Assessment Report Addendum

, 2019
Leslie Eudy, R. Burgess, Chris Ainscough, John H. Lewis   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

tRNA-dependent conformational dynamics and folding coordinate translational regulation by a full-length T-box riboswitch. [PDF]

Nat Commun
Niu X, Cai S, Wang J, Chen C, Fang X.
europepmc   +1 more source

Transitions [PDF]

Journal of Pastoral Care & Counseling: Advancing theory and professional practice through scholarly and reflective publications, 2015
openaire   +2 more sources

CHEOPS: a space telescope for ultra-high precision photometry of exoplanet transits

International Conference on Space Optics, 2017
T. Beck, C. Broeg, D. Ehrenreich, G. Peter, D. Magrin, J. Plesseria, J. Szőke, F. Wildi, V. Cessa, W. Benz, A. Fortier, I. Pagano, M. Steller, N. Thomas, R. Ragazzoni   +14 more
semanticscholar   +1 more source