Results 291 to 300 of about 363,457 (364)

An Investigation of Routing Strategies To Improve Transit Service

, 1998
David P. Racca
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

MOST DETECTS TRANSITS OF HD 97658b, A WARM, LIKELY VOLATILE-RICH SUPER-EARTH

, 2013
D. Dragomir, J. Matthews, J. Eastman, C. Cameron, A. Howard, D. Guenther, R. Kuschnig, A. Moffat, J. Rowe, S. Rucinski, D. Sasselov, W. Weiss   +11 more
semanticscholar   +1 more source

The Effect of In Vivo Dissolution, Gastric Emptying Rate, and Intestinal Transit Time on the Peak Concentration and Area-Under-the-Curve of Drugs with Different Gastrointestinal Permeabilities

, 1999
Lydia C. Kaus, William R. Gillespie, Ajaz Hussain, Gordon L. Amidon   +3 more
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

An ultra-short-period super-Earth with an extremely high density and an outer companion. [PDF]

Sci Rep
Livingston JH, Gandolfi D, Trani AA, Herath M, Barragán O, Hatzes A, Luque R, Fukui A, Nowak G, Palle E, Hellier C, Fridlund M, de Leon J, Hirano T, Narita N, Albrecht S, Dai F, Deeg H, Van Eylen V, Korth J, Tamura M.   +20 more
europepmc   +1 more source

Guideway Transit and Intermodalism: Function and Effectiveness: Case Study, Pittsburgh

, 1996
Mitchell P. York
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Identifying and minimizing primary sources of temporal broadening in online affinity micro free-flow electrophoresis. [PDF]

Analyst
Burke GS, Bowser MT.
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source