Results 321 to 330 of about 363,457 (364)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Spatio-temporal patterns in growing bacterial suspensions. [PDF]

Sci Rep
Jena P, Mishra S.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A transiting giant planet in orbit around a 0.2-solar-mass host star. [PDF]

Nat Astron
Bryant EM, Jordán A, Hartman JD, Bayliss D, Sedaghati E, Barkaoui K, Chouqar J, Pozuelos FJ, Thorngren DP, Timmermans M, Almenara JM, Chilingarian IV, Collins KA, Gan T, Howell SB, Narita N, Palle E, Rackham BV, Triaud AHMJ, Bakos GÁ, Brahm R, Hobson MJ, Van Eylen V, Amado PJ, Arnold L, Bonfils X, Burdanov A, Cadieux C, Caldwell DA, Casanova V, Charbonneau D, Clark CA, Collins KI, Daylan T, Dransfield G, Demory BO, Ducrot E, Fernández-Rodríguez G, Fukuda I, Fukui A, Gillon M, Gore R, Hooton MJ, Ikuta K, Jehin E, Jenkins JM, Levine AM, Littlefield C, Murgas F, Nguyen K, Parviainen H, Queloz D, Seager S, Sebastian D, Srdoc G, Vanderspek R, Winn JN, de Wit J, Zúñiga-Fernández S.   +58 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A new method for correcting the refraction angle of starlight under the conditions of 0-[Formula: see text] zenith distance and 0-200 km observation height. [PDF]

Sci Rep
Yu D, Wang Y, Huang Z, Liu X.
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Temporal trend of microenvironmental time-activity patterns of the Seoul population from 2004 to 2022 and its potential impact on exposure assessment. [PDF]

J Expo Sci Environ Epidemiol
Kim D, Guak S, Lee K.
europepmc   +1 more source