Results 31 to 40 of about 84,662 (294)
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Transits maghrébins à Istanbul. Trajectoires, profils et stratégies
Since the beginning of the 1990’s, Istanbul has become a focal point, both polarizing and re-dispatching the flows in the international transit migration system set up between Europe and poor countries.
Jean-François Pérouse
doaj +1 more source
New observations and transit solutions of the exoplanets HAT-P-54b and WASP-153b [PDF]
We present photometric observations of the newly-discovered transiting exoplanets HAT-P-54b and WASP-153b with the Rozhen 2 m telescope. As a result we improved their periods.
Kjurkchieva Diana+2 more
doaj +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke+2 more
wiley +1 more source
Este artículo busca poner en escena y analizar ciertos tránsitos, heterogéneos en su consumación, en el cine latinoamericano (2000-2010). Indaga, a partir de algunas reflexiones de Marc Augé, Isaac Joseph y Michel de Certau, las posibilidades de tránsito,
Luis Valenzuela Prado
doaj
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Autophagy in cancer and protein conformational disorders
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang+2 more
wiley +1 more source
The Colorado Ultraviolet Transit Experiment Mission Overview
Atmospheric escape is a fundamental process that affects the structure, composition, and evolution of many planets. The signatures of escape are detectable on close-in, gaseous exoplanets orbiting bright stars, owing to the high levels of extreme ...
Kevin France+20 more
doaj +1 more source