Results 91 to 100 of about 2,536,108 (315)

Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage

iScience, 2019
Summary: Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to elucidate the translation ...
Abhishek Guha, Deepika Ahuja, Sukhen Das Mandal, Bibudha Parasar, Krishanu Deyasi, Debadrita Roy, Vasundhara Sharma, Belinda Willard, Anandamohan Ghosh, Partho Sarothi Ray   +9 more
doaj   +1 more source

IRES-mediated cap-independent translation, a path leading to hidden proteome

Journal of Molecular Cell Biology, 2019
Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) can serve as an alternative mechanism for protein production.
Yun Yang, Zefeng Wang
semanticscholar   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

History of Molecular Biology Michel Morange and translated by Matthew Cobb [PDF]

, 2002
John P. Welch
openalex   +1 more source

Translation Techniques of the Complex Sentences in Bilingual Textbook Biology 1 For Senior High School Year X Published by Yudhistira

ELT Forum: Journal of English Language Teaching, 2013
This final project was a study which analyzed the use of translation techniques in the bilingual textbook BIOLOGY 1for Senior High School Year X Published by Yudhistira. The study was done qualitatively.
Ikma Qurrota A'yun
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

Nature Cell Biology, 2022
R. Su, Lei Dong, Yangchan Li, Min Gao, P. He, Wei Liu, Jiangbo Wei, Zhicong Zhao, Lei Gao, Li Han, Xiaolan Deng, Chenying Li, Emily A. Prince, B. Tan, Y. Qing, Xi Qin, Chao Shen, Meilin Xue, Keren Zhou, Zhenhua Chen, Jingling Xue, Wei Li, H. Qin, Xiwei Wu, Miao Sun, Y. Nam, C. Chen, Wendong Huang, D. Horne, Steven T Rosen, C. He, Jianjun Chen   +31 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Exosomes and Microvesicles: from Stem Cell Biology to Translation in Human Diseases [PDF]

, 2021
Giovanni Camussi
openalex   +1 more source

Functional Translational Readthrough: A Systems Biology Perspective.

PLoS Genetics, 2016
Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR).
Fabian Schueren, Sven Thoms
doaj   +1 more source