The Distinct Biological Effects of 6-Hydroxy-L-Nicotine in Representative Cancer Cell Lines
Molecules6-hydroxy-L-nicotine (6HLN) is a nicotine (NIC) derivative with proven therapeutic potential in neurodegenerative disorders. Here, the impact of 6HLN on cell growth, migratory behavior, and inflammatory status of three different cancer cell lines (A549 ...
Paula Alexandra Postu +5 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
History of Molecular Biology Michel Morange and translated by Matthew Cobb [PDF]
, 2002 John P. Welch
openalex +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X
Molecular Systems BiologyThe road from transcription to protein synthesis is paved with many obstacles, allowing for several modes of post-transcriptional regulation of gene expression.
Ziad Jowhar +7 more
doaj +1 more source
History of Molecular Biology Michel Morange (translated by Matthew Cobb) [PDF]
, 2003 John P. Welch
openalex +1 more source
Meeting the Challenge of Systems Biology in Traumatic Brain Injury: Beginning Reverse Translation with Epigenome-Wide Association Studies [PDF]
, 2022 Paul Nyquist
openalex +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
Postgenomic futures: translations across the machine-nature border in systems biology [PDF]
, 2005 Joan H. Fujimura
openalex +1 more source
Translational In Vivo Assays in Behavioral Biology
Annual Review of Pharmacology and ToxicologyThe failure of preclinical research to advance successful candidate medications in psychiatry has created a paradigmatic crisis in psychiatry. The Research Domain Criteria (RDoC) initiative was designed to remedy this situation with a neuroscience-based approach that employs multimodal and cross-species in vivo methodology to increase the probability ...
Sarah L, Withey +2 more
openaire +2 more sources