Results 181 to 190 of about 2,947,154 (398)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Oxa1 Directly Interacts with Atp9 and Mediates Its Assembly into the Mitochondrial F\u3csub\u3e1\u3c/sub\u3eF\u3csub\u3eo\u3c/sub\u3e-ATP Synthase Complex [PDF]

, 2007
The yeast Oxa1 protein is involved in the biogenesis of the mitochondrial oxidative phosphorylation (OXPHOS) machinery. The involvement of Oxa1 in the assembly of the cytochrome oxidase (COX) complex, where it facilitates the cotranslational membrane ...
Dienhart, Mary Kathryn, Jia, Lixia, Stuart, Rosemary A.   +2 more
core   +1 more source

Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX®Colon Cancer Assay [PDF]

, 2010
Kim M. Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar, Drew Watson   +3 more
openalex   +1 more source

Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation [PDF]

, 2023
Puneet Tyagi, Chandresh Patel, Kimberly Gibson, Fiona MacDougall, Sergei Pechenov, Sarah Will, Jefferson D. Revell, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Umar S. M. Maharoof, Joseph Grimsby, J. Anand Subramony   +12 more
openalex   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Editorial: Inflammation, Thrombosis and Vascular Biology: Translating Ideas into Cardiovascular Research and Therapy [PDF]

, 2010
Armen Yuri Gasparyan
openalex   +1 more source

Comments on roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation [PDF]

, 2023
María José Serrano, Umberto Malapelle
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Assembly of the precursor and processed light-harvesting chlorophyll a/b protein of Lemna into the light-harvesting complex II of barley etiochloroplasts. [PDF]

, 1986
When the in vitro synthesized precursor of a light-harvesting chlorophyll a/b binding protein (LHCP) from Lemna gibba is imported into barley etiochloroplasts, it is processed to a single form.
Chitnis, PR, Harel, E, Kohorn, BD, Thornber, JP, Tobin, EM   +4 more
core   +1 more source

The biology of brain metastases—translation to new therapies [PDF]

, 2011
April F. Eichler, Euiheon Chung, David P. Kodack, Jay S. Loeffler, Dai Fukumura, Rakesh K. Jain   +5 more
openalex   +1 more source