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Translational biology of osteosarcoma
Nature Reviews Cancer, 2014For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing.
Kansara, Maya +3 more
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Translating connexin biology into therapeutics
Seminars in Cell & Developmental Biology, 2016It is 45 years since gap junctions were first described. Universities face increasing commercial pressures and declining federal funding, with governments and funding foundations showing greater interest in gaining return on their investments. This review outlines approaches taken to translate gap junction research to clinical application and the ...
Anthony R. J. Phillips +4 more
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Biology, biography, and the translational gap
Science Translational Medicine, 2019Medicine-based evidence integrates biology and biography to help eliminate the translational gap between research and the clinic.
Pamela Summers-Trio +3 more
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Translational environmental biology: cell biology informing conservation
Trends in Cell Biology, 2014Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate immunity and acclimatization have ...
Nikki Traylor-Knowles +1 more
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Molecular biology of translation in yeast
Antonie van Leeuwenhoek, 1992The combination of genetic, molecular and biochemical approaches have made the yeast Saccharomyces cerevisiae a convenient organism to study translation. The sequence similarity of translation factors from yeast and other organisms suggests a high degree of conservation in the translational machineries.
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Annual Review of Microbiology, 2008
The trans-translation mechanism is a key component of multiple quality control pathways in bacteria that ensure proteins are synthesized with high fidelity in spite of challenges such as transcription errors, mRNA damage, and translational frameshifting. trans-Translation is performed by a ribonucleoprotein complex composed of tmRNA, a specialized RNA
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The trans-translation mechanism is a key component of multiple quality control pathways in bacteria that ensure proteins are synthesized with high fidelity in spite of challenges such as transcription errors, mRNA damage, and translational frameshifting. trans-Translation is performed by a ribonucleoprotein complex composed of tmRNA, a specialized RNA
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Translating cancer research by synthetic biology
Molecular BioSystems, 2011Synthetic biology concerns applying engineering principles to biological systems. Engineering properties such as fine tuning, novel specificity, and modularity could be components of a synthetic toolkit that can be exploited to explore various issues in cancer research such as elucidation of mechanisms and pathways, creating new diagnostic tools and ...
Sumitra Shankar, M. Radhakrishna Pillai
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