A painting art rendering system by deep learning framework and machine translation. [PDF]
Wang S, Shahir S, Ismail MU.
europepmc +1 more source
Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim +16 more
wiley +1 more source
Conceptions of geography teaching: Dataset enabling typology transfer and teaching quality reflection in other fields. [PDF]
Knecht P, Spurná M, Soukup P.
europepmc +1 more source
Learned Conformational Space and Pharmacophore Into Molecular Foundational Model
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang +8 more
wiley +1 more source
Evaluation of Japanese instructor experiences in the first overseas BLS course certified by the Japanese association for acute medicine in Cambodia: a mixed-methods analysis using text mining. [PDF]
Ooya Y +5 more
europepmc +1 more source
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
4D-Morphing biopolymers in reconstructive plastic surgery: implications, challenges and a call for clinical-translation. [PDF]
Amjad A, Waqar M, Ali U, Mahato RK.
europepmc +1 more source
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Enhancing Maritime Safety Through Needs Analysis: Identifying Critical English Communication Skills for Pre-Service Maritime Students in a Chinese University. [PDF]
Guo X, Zhen M, Guo Y.
europepmc +1 more source

