Results 111 to 120 of about 404,871 (284)

The New Role of Academia in Drug Development [PDF]

, 2010
Recommends ways for government, nonprofits, and academic institutions to work with the private sector to develop drugs and bring them to market more efficiently, including establishing models for intellectual property and technology transfer ...

core  

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Patient-derived tumor organoids: advances, applications, and future directions in biomedical research

Frontiers in Medicine
Patient-derived tumor organoids (PDTOs) have become a key tool in cancer and translational oncology because they are physiologically relevant, 3D in vitro systems that preserve the genetic, epigenetic and phenotypic features of patient tumors.
Ahmet Acar
doaj   +1 more source

StarBRITE: The Vanderbilt University Biomedical Research Integration, Translation and Education portal

Journal of Biomedical Informatics, 2011
StarBRITE is a one-stop, web-based research portal designed to meet the day-to-day needs of the Vanderbilt University and Meharry Medical College research community during the planning and conduct of research studies. StarBRITE serves as the main online location for research support addressing issues such as identification and location of resources ...
Harris, Paul A., Swafford, Jonathan A., Edwards, Terri L., Zhang, Minhua, Nigavekar, Shraddha S., Yarbrough, Tonya R., Lane, Lynda D., Helmer, Tara, Lebo, Laurie A., Mayo, Gail, Masys, Daniel R., Bernard, Gordon R., Pulley, Jill M.   +12 more
openaire   +2 more sources

Unlocking the Power of Quercetin‐Encapsulated Mesoporous Bioactive Glass Nanoparticles: A Multifunctional Approach to Bone Regeneration

Advanced Engineering Materials, EarlyView.
Mesoporous bioactive glass nanoparticles (MBGNs) are investigated for bone regeneration given their remarkable structural and functional properties. MBGNs are functionalized with Mn and Cu and incorporated with quercetin, a natural flavonoid exhibiting antioxidant, anti‐inflammatory, and antimicrobial properties.
Giovanni Lo Bello, Qaisar Nawaz, Pier Francesco Ferrari, Laura Pastorino, Roberto Raiteri, Aldo R. Boccaccini   +5 more
wiley   +1 more source

Paradigm shift required for translational research on the brain

Experimental and Molecular Medicine
Biomedical research on the brain has led to many discoveries and developments, such as understanding human consciousness and the mind and overcoming brain diseases.
Jong Hyuk Yoon, Dongha Lee, Chany Lee, Eunji Cho, Seulah Lee, Amaury Cazenave-Gassiot, Kipom Kim, Sehyun Chae, Edward A. Dennis, Pann-Ghill Suh   +9 more
doaj   +1 more source

Pioneer Valley Life Sciences Institute Translational Biomedical Research

, 2012
1. Analysis of angiogenic factors in breast cancer angiogenesis. Determine whether Acheron and YKL-40 were elevated in subsets of primary breast cancers and if they participated directly in determining the behavior of tumors. 2. Use of polymers for chemotherapeutic delivery to breast cancer tumors. The experiments were designed to define the utility of
Sallie Schneider, Rong Shao, Lawrence Schwartz, D Joseph Jerry   +3 more
openaire   +2 more sources

Microstructural Evolution and Mechanical Performance of Plasma‐Assisted Hybrid Friction Stir Welded Dissimilar Aluminum–Copper Joints

Advanced Engineering Materials, EarlyView.
Plasma‐assisted hybrid friction stir welding of dissimilar AlCu joints employs localized plasma preheating to balance heat input and enhance plastic flow. The optimized process reduces axial force by up to 35%, refines the microstructure, and achieves ≈96% joint efficiency.
Deepak Kumar Yaduwanshi, Pankaj Shrivastava, Ganesh Chouhan, Velaphi Msomi   +3 more
wiley   +1 more source

The interrelation of scientific, ethical, and translational challenges for precision medicine with multimodal biomarkers – A qualitative expert interview study in dermatology research

Heliyon
This qualitative study examines the impact of scientific, ethical, and translational challenges of precision medicine for atopic dermatitis and psoriasis. The study explores how these challenges affect biomarker research for inflammatory skin diseases as
Nora Hangel, Alena Buyx, Marie-Christine Fritzsche   +2 more
doaj   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source