Results 121 to 130 of about 1,207,203 (260)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Gaps and paths forward in cancer pharmacology and translational research. [PDF]

Front Pharmacol
Hughes EA, Davenport LL, Zdyrski C, Pawlak A, Mochel JP, Douglass EF.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Clinical translational research on stem cell products: prospects and challenges. [PDF]

Signal Transduct Target Ther
Chen S, Zhang L, Ren Y, Bai X, Wei X, Chai M, Cui S, Zhao X, Deng H.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Epidermolysis bullosa and global challenges in translational research for rare diseases. [PDF]

Einstein (Sao Paulo)
Martin PKM, Viana LKL, Sanfins MD.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Neurogenética en el Perú, ejemplo de investigación traslacional

Revista Peruana de Medicina Experimental y Salud Pública
La neurogenética es una disciplina emergente en el Perú que vincula la investigación básica con la práctica clínica. El Centro de Investigación Básica en Neurogenética, es el único centro en el Perú dedicado a la atención especializada de enfermedades ...
Pilar Mazzetti, Miguel Inca-Martínez, Indira Tirado-Hurtado, Karina Milla-Neyra, Gustavo Silva-Paredes, Anastasia Vishnevetsky, Mario Cornejo-Olivas   +6 more
doaj  

TRANSLATIONAL CKD RESEARCH [PDF]

Nephrology Dialysis Transplantation, 2014
Freedman, B.S., Lam, A.Q., Sundsbak, J.L., Morizane, R., Iatrino, R., Su, X., Koon, S.J., Wu, M., Daheron, L., Valerius, T., Harris, P.C., Zhou, J., Bonventre, J.V., Hwang, S.J., Lin, M.Y., Lee, H.L., Lin, H.L., Li, W.M., Wu, W.J., Huang, C.H., Chen, L.T., Yazawa, M., Kido, R., Kimura, K., Ohira, S., Hasegawa, T., Hanafusa, N., Iseki, K., Tsubakihara, Y., Shibagaki, Y., Kotwal, S., Webster, A., Cass, A., Gallagher, M, Raimann, J.G., Usvyat, L.A., Vega-Vega, O., Penne, L., Kooman, J., van der Sande, F.M., Thijssen, S., Marcelli, D., Canaud, B., Levin, N.W., Wang, Y., Kotanko, P., Tripepi, G., Maas, R., Boger, R., Zoccali, C., Mallamaci, F.   +50 more
openaire   +1 more source