Results 231 to 240 of about 451,700 (244)

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Genetic Deficiency of Interleukin-4 and Interleukin-13 Exacerbates Alcohol- and Cigarette Smoke-Associated Chronic Pancreatitis via the Pancreas-Intestine Axis. [PDF]

Gastro Hep Adv
Wang J, Shams Azar PR, Apte MV, Pandol SJ, Husain SZ, Lee B.   +5 more
europepmc   +1 more source

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Extra-skeletal Ewing's sarcoma with EWSR1::ERG translocation of the breast: a case report. [PDF]

Diagn Pathol
Li W, Wu Y, Dong X, Qiu X, Zheng G, Zhang Y.   +5 more
europepmc   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Identification of De Novo Chromosomal Translocations Disrupting NIPBL in a Patient With Cornelia de Lange Syndrome by Full Genome Analysis. [PDF]

Mol Genet Genomic Med
Kao HJ, Wang EHF, Yeh EC, Chen HH, Hsieh FJ, Ko TM, Hwu WL, Kwok PY, Lee NC.   +8 more
europepmc   +1 more source

Global genomic population structure of wild and cultivated oat reveals signatures of chromosome rearrangements. [PDF]

Nat Commun
Bekele WA, Avni R, Birkett CL, Itaya A, Wight CP, Bellavance J, Brodführer S, Canales FJ, Carlson CH, Fiebig A, Li Y, Michel S, Nandety RS, Waring DJ, Arbelaez JD, Beattie AD, Caffe M, Del Blanco IA, Fiedler JD, Gupta R, Gutierrez L, Harris JC, Harrison SA, Herrmann MH, Huang YF, Isidro Y Sanchez J, McMullen MS, Mitchell Fetch JW, Nilsen KT, Parkin IAP, Peng Y, Smith KP, Sutton T, Yan W, Zwer P, Diederichsen A, Esvelt Klos K, Fu YB, Howarth CJ, Jannink JL, Jellen EN, Langdon T, Maughan PJ, Paczos-Grzeda E, Prats E, Sen TZ, Mascher M, Tinker NA.   +47 more
europepmc   +1 more source

Nanopore-based sensing for biomarker detection: from fundamental principles to translational diagnostics. [PDF]

J Nanobiotechnology
Shrikrishna NS, Gandhi S.
europepmc   +1 more source

Risk Assessment and Fertility Counseling for Hereditary Gynecological Cancer Syndromes. [PDF]

Cancer Med
Zhao M, Teng XM, Yan Q, Hao F.
europepmc   +1 more source