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Translocations as Genetic Markers
1994If two nonhomologous chromosomes interchange ends following chromosome breakage, the products of this event are termed a reciprocal interchange or reciprocal translocation. The two rearranged chromosomes that result are fully stable and, when transmitted together, contain all the chromosomal material that was present in the two normally arranged ...
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The Role of Translocation and Selection in the Emergence of Genetic Clusters and Modules
Artificial Life, 2007Biomolecular studies point increasingly to the importance of modularity in the organization of the genome. Processes such as the maintenance of metabolism are controlled by suites of genes that act as distinct, self-contained units, or modules. One effect is to promote stability of inherited characters. Despite the obvious importance of genetic modules,
David Newth, David G. Green
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Protein translocation genetics
1995Publisher Summary This chapter presents the update to the progress in studies of the protein translocation system in E. coli, with emphasis placed on genetic analyses of the translocation machinery. It is suggested that the significance of genetic analysis is at least two-fold.
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Gross Deletions and Translocations in Human Genetic Disease
2006Translocations and gross deletions constitute an important cause of both cancer and inherited disease. Such gene rearrangements are non-randomly distributed in the human genome as a consequence of selection for growth advantage and/or the inherent potential of some DNA sequences to be frequently involved in breakage and recombination.
S S, Abeysinghe +2 more
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Monitoring and detecting translocations using genetic data
2001Review on the possiblity to detect and monitor translocation events using genetic data for conservation biology ...
BERTORELLE, Giorgio +3 more
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[Robertsonian translocation and genetic counseling].
Journal de genetique humaine, 1988A collaborative study on 92 Robertsonian translocations is analysed in relation with the methods of ascertainment, the type of rearrangement and potential imbalance of the anomaly. The results are useful in genetic counselling.
L F, Formiga +3 more
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The SecY translocation complex: convergence of genetics and structure
Trends in Microbiology, 2007All organisms share a requirement for translocation of proteins across membranes. The major mechanism for this process is the universally conserved SecY/Sec61 pathway. Many years of extensive genetic and biochemical analyses identified the components of the SecY/Sec61 pathway, demonstrated that most exported proteins use this route for translocation ...
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[Preimplantation genetic diagnosis of translocation].
Zhonghua fu chan ke za zhi, 2011To observe the genetic characteristics of chromosomes and the rates of implantation and pregnancy in couples of translocation carriers who undergo preimplantation genetic diagnosis (PGD) and to evaluate the significance of PGD in the treatment of translocation carriers.Fluorescence in situ hybridization (FISH) was performed to analyze the embryos of 12
Yu-Li, Qian +5 more
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Journal of Bioenergetics and Biomembranes, 1990
Recent years have seen the convergence of both genetic and biochemical approaches in the study of protein translocation in E. coli. The powerful combination of these approaches is exemplified in the use of an in vitro protein synthesis-protein translocation system to analyze the role of genetically defined components of the protein translocation ...
J, Fandl, P C, Tai
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Recent years have seen the convergence of both genetic and biochemical approaches in the study of protein translocation in E. coli. The powerful combination of these approaches is exemplified in the use of an in vitro protein synthesis-protein translocation system to analyze the role of genetically defined components of the protein translocation ...
J, Fandl, P C, Tai
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Variant translocations (9;11): Identification of the critical genetic rearrangement
Cancer Genetics and Cytogenetics, 1988The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported.
B N, Harris +6 more
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