Results 91 to 100 of about 5,841,576 (327)

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Bousema, Teun, Drakeley, Chris J, Ghani, Azra C, Okell, Lucy C, Sutherland, Colin J   +4 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Financial Transmission Rights (FTR) as a Congestion Management Scheme in Electricity Transmission: Strategic Behavior in a Coupled FTR — Electricity Market Model [PDF]

, 2015
With the emergence of liberalized markets, transmission line congestion has been a prominent technical constraint that has to be accounted for in designing the new markets.
Oruc, S.
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Bending stress analysis of orthogonal curve-face gear

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
In order to solve the time-varying bending bearing capacity of orthogonal curve-face gear, we proposed the calculation and test method of bending stress of gear tooth root.
Yao WANG, Chao LIN, Zhiqin CAI, Chao HUANG   +3 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Geometry generation principle and meshing properties of a new gear drive

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
The generation principle of composite cycloid is proposed for the tooth profile of external drive. Firstly, a two-link mechanism is developed as the equivalent mechanism to describe the geometric principle of cycloid by introducing the motion ...
Zhenhua HAN, Wankai SHI, Chang LIU, Lang XU   +3 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Study on the Corrosion Behavior of Grounding Materials in Acidic Soils With Different Cl− Contents

International Journal of Electrochemistry
The grounding system is a key infrastructure that ensures the stable and safe operation of the power system. The corrosion behavior of earthing materials within soil environments significantly impacts their long-term reliability. This article studies the
Yan Jin, Yiliang Lu, Qiang Zhang, Yun Chen, Xiaofang Wang, Bingkun Yang   +5 more
doaj   +1 more source

Characteristics of Additional Load Losses of Spindle System of Machine Tools

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
Energy consumption of machine tool has drawn wide attention in recent years. The additional load losses of machine tools are of great importance for investigating the energy consumption of machine tools because those account for 15-20% of the cutting ...
Shaohua HU, Fei LIU, Yan HE, Bin PENG
doaj   +1 more source