Results 51 to 60 of about 32,503 (258)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Design of Visualization Interface for Transmission Congestions

Energy Procedia, 2017
Abstract Visualization has been extensively applied in many areas, especially for the management of massive data and the display interface area. However, the complexity of grid connections in a large-scale power system is a challenging issue. For an efficient power system operation, it is necessary for electrical engineers and operators to analyze ...
Yuan-Kang Wu, Xiu-Chang Lee, Che-Yi Hu, Po-En Su   +3 more
openaire   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Multiobjective Optimization Methods for Congestion Management in Deregulated Power Systems

Journal of Electrical and Computer Engineering, 2012
Congestion management is one of the important functions performed by system operator in deregulated electricity market to ensure secure operation of transmission system. This paper proposes two effective methods for transmission congestion alleviation in
K. Vijayakumar
doaj   +1 more source

A General and Efficient Framework for the Rapid Design of Miniaturized, Wideband, and High‐Bit RIS

Advanced Electronic Materials, EarlyView.
A general and efficient framework is proposed for the rapid design of high‐performance reconfigurable intelligent surfaces (RISs). This framework integrates advanced antenna design techniques and incorporates various load types, quantities, and values to achieve the design of high‐performance RISs.
Jun Wei Zhang, Zheng Xing Wang, Wanwan Cao, Zhen Jie Qi, Li Jie Wu, Han Qing Yang, Qun Yan Zhou, Si Ran Wang, Hui Dong Li, Jun Yan Dai, Jiang Luo, Jun Wei Wu, Jia Nan Zhang, Zhen Zhang, Qiang Cheng   +14 more
wiley   +1 more source

Adaptive message sending rate control method based on channel congestion cost calculation in VANET

Tongxin xuebao, 2016
In VANET,sending beacon messages reliably played a vital role in cooperative awareness and collision avoidance,and changes of vehicle density in real traffic environment had a direct impact on channel load and will cause the channel congestion to a ...
Ming-jian LIU, Guo-zhen TAN, Shuai-bing LI, Nan DING, Cai-xia SONG   +4 more
doaj   +2 more sources

CONGESTION MANAGEMENT IN TRANSMISSION NETWORK

Journal of Energy : Energija, 2005
With electric energy market opening including all accompanying consequences (restructuring of electric power companies, unbundling, legislation change, creation of market and system operator, energy sector regulation, privatisation), conditions of transmission network operation and development planning have strongly changed.
Majstrović, Goran, Dizdarević, Nijaz, Bajs, Davor   +2 more
openaire   +1 more source

The Geography of Success: A Spatial Analysis of Export Intensity in the Italian Wine Industry

Agribusiness, EarlyView.
ABSTRACT This paper investigates the paradox of how Italy's fragmented, SME‐dominated wine industry achieves global export success. Moving beyond purely firm‐centric explanations, we test whether export intensity is spatially dependent, clustering geographically in regional ecosystems.
Nicolas Depetris Chauvin, Jonas Di Vita
wiley   +1 more source

When the River Runs Low: Heterogeneous Impacts of Transportation Disruptions on Local Grain Basis

Agribusiness, EarlyView.
ABSTRACT A substantial share of U.S. soybean and corn exports from the Midwest moves by barge along the Mississippi River system to export terminals in the Louisiana Gulf. Transportation costs between Midwestern grain elevators and export terminals create a wedge between prices at these locations, and shocks to these costs are partially passed on to ...
Yuan Zhang, Andrew E. Anderson, Nicholas J. Pates, Eunchun Park   +3 more
wiley   +1 more source