Results 41 to 50 of about 290,940 (297)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Atomic Fabrication of 2D Materials Using Electron Beams Inside an Electron Microscope

Nanomaterials
Two-dimensional (2D) materials have garnered increasing attention due to their unusual properties and significant potential applications in electronic devices.
Mingrui Zhou, Wei Zhang, Jinyi Sun, Fuqiang Chu, Guocai Dong, Meng Nie, Tao Xu, Litao Sun   +7 more
doaj   +1 more source

Effects of Extremely Low Frequency Electromagnetic Fields and Simultaneous Treatment with Allium Cepa on Biochemical Parameters and Ultrastructure of Ovarian Tissues of Rats [PDF]

Iranian Journal of Medical Physics, 2019
Introduction: This study investigated the effects of extremely low frequency electromagnetic fields (ELF-EMF) (50 Hz, 3 mT) on biochemical parameters of rats’ ovarian tissues and the impact of Allium cepa on the reduction of potential adverse influences ...
Elham Mansouri, Ahmad Keshtkar, Arash Khaki, Ehsan Keshtkar, Afshin Khaki   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A Novel Microchip Technique for Quickly Identifying Nanogranules in an Aqueous Solution by Transmission Electron Microscopy: Imaging of Platelet Granules

Applied Sciences, 2020
Ultrastructural observation of biological specimens or nanogranules usually requires the use of electron microscopy. Electron microscopy takes a lot of time, requires many steps, and uses many chemicals, which may affect the native state of biological ...
Nguyen Thi Thu Trang, Jungshan Chang, Wei-An Chen, Chih-Chun Chen, Hui-Min Chen, Chao-Chien Chang, Tsorng-Harn Fong   +6 more
doaj   +1 more source

Detection of nanoparticles by means of reflection electron energy loss spectroscopy depth profiling [PDF]

, 2013
The various studies of nanoparticles are of great importance because of the wide application of nanotechnology. The shape and structure of the nanoparticles can be determined by transmission electron microscopy (TEM) and their chemistry by electron ...
Menyhárd, Miklós
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

A nanofabricated, monolithic, path-separated electron interferometer

Scientific Reports, 2017
Progress in nanofabrication technology has enabled the development of numerous electron optic elements for enhancing image contrast and manipulating electron wave functions.
Akshay Agarwal, Chung-Soo Kim, Richard Hobbs, Dirk van Dyck, Karl K. Berggren   +4 more
doaj   +1 more source

Effect of carbon quantum dots on the photo‐absorption, photo‐response and photoelectrochemical performance of KNb3O8 film photoelectrode

Micro & Nano Letters, 2021
The KNb3O8 crystals and carbon quantum dots were synthesized via hydrothermal reaction method, their crystal structural and morphological properties were investigated by X‐ray diffraction, scanning electron microscope and transmission electron microscope,
Xiaobin Liu, Tianjian Tan, Wenxiu Que, Huanfu Zhou, Kangguo Wang   +4 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source