Results 51 to 60 of about 859,730 (289)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Post-Irradiation Annealing of Bi Ion Tracks in Si₃N₄: In-Situ and Ex-Situ Transmission Electron Microscopy Study

Crystals
High-energy (710 MeV) Bi ion track morphology in polycrystalline silicon nitride was investigated during post-irradiation annealing. Using both in-situ and ex-situ transmission electron microscopy, we monitored the recovery of crystallinity within ...
Anel Ibrayeva, Jacques O’Connell, Ruslan Rymzhanov, Arno Janse van Vuuren, Vladimir Skuratov   +4 more
doaj   +1 more source

Synthesis and characterization of spherical amorphous alumo-silicate nanoparticles using RF thermal plasma method [PDF]

, 2013
The RF thermal plasma synthesis route was used for the preparation of alumo-silicate spherical particles. Homogeneous solid mixtures of raw materials (Al2O3, SiO2 and KOH) were used as precursors.
Jankeviciutea, Audrone, Kareivaa, Aivaras, Károly, Zoltán, Szépvölgyi, János, Tarakinac, Nadezda V.   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Metabolic and ultrastructural renal changes in adult Wistar rats fed by a cafeteria diet [PDF]

Acta Cirúrgica Brasileira
Purpose: To evaluate, by quantitative and qualitative methods, the glomerular ultrastructure in Wistar rats fed a cafeteria diet. Methods: Male Wistar rats were divided into two groups at 21 days of age: control (C, n = 10) and cafeteria diet (CAF, n ...
Priscila Fernandes dos Santos, Diogo Benchimol de Souza, Eduardo José Lopes Torres, Waldemar Silva Costa, Francisco José Barcellos Sampaio, Bianca Martins Gregorio   +5 more
doaj   +1 more source

Cryogenic transmission electron microscopy nanostructural study of shed microparticles. [PDF]

PLoS ONE, 2013
Microparticles (MPs) are sub-micron membrane vesicles (100-1000 nm) shed from normal and pathologic cells due to stimulation or apoptosis. MPs can be found in the peripheral blood circulation of healthy individuals, whereas elevated concentrations are ...
Liron Issman, Benjamin Brenner, Yeshayahu Talmon, Anat Aharon   +3 more
doaj   +1 more source

Nanoscale diffractive probing of strain dynamics in ultrafast transmission electron microscopy [PDF]

, 2017
The control of optically driven high-frequency strain waves in nanostructured systems is an essential ingredient for the further development of nanophononics. However, broadly applicable experimental means to quantitatively map such structural distortion
da Silva, Nara Rubiano, Feist, Armin, Liang, Wenxi, Ropers, Claus, Schäfer, Sascha   +4 more
core   +4 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Cryogenic transmission electron microscopy of recombinant tuberculosis vaccine antigen with anionic liposomes reveals formation of flattened liposomes

International Journal of Nanomedicine, 2014
Christopher B Fox,1 Sean K Mulligan,2 Joyce Sung,2 Quinton M Dowling,1 H W Millie Fung,1 Thomas S Vedvick,1 Rhea N Coler1 1Infectious Disease Research Institute, Seattle, WA, USA; 2NanoImaging Services, La Jolla, CA, USA Abstract: Development of lipid ...
Fox CB, Mulligan SK, Sung J, Dowling QM, Fung HWM, Vedvick TS, Coler RN   +6 more
doaj