Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Deep Reinforcement Learning for Joint Trajectory Planning, Transmission Scheduling, and Access Control in UAV-Assisted Wireless Sensor Networks. [PDF]
Luo X +5 more
europepmc +1 more source
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Simulation analysis of probabilistic covert channels based on probabilistic interference
Bandwidth and transmission error rate has received much attention in fields of covert channels.If a system does not satisfy BSPNI,PBNDC or SPBNDC property,then probabilistic covert channels will be formed.A simulation system was built to analyze their ...
GUO Yun-chuan1 +3 more
doaj +2 more sources
A nationwide student survey on biochemistry learning resources in Italy
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti +4 more
wiley +1 more source
Energy-Efficient Secure Transmission Design for the Internet of Things With an Untrusted Relay
In this paper, we investigate secure uplink transmission in a typical Internet of Things (IoT) deployment, where multiple sensors communicate with a controller via the assistance of an untrusted relay.
Dechuan Chen +4 more
doaj +1 more source
Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
Scheduling for telemedicine traffic transmission over WLANs [PDF]
The major disadvantage of the Enhanced Distributed Channel Access (EDCA, the contention-based channel access function of 802.11e) is that it is unable to guarantee priority access to higher priority traffic in the presence of significant traffic loads from low priority users.
openaire +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source

