Results 51 to 60 of about 108,303 (268)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The State of the Art of Research on Power Supply Technologies for Moving Targets

Energies
With the advancement of power electronics, control systems, and related technologies, devices such as unmanned aerial vehicles (UAVs), airships, and electric vehicles (EVs) have become integral to modern life and industry.
Man Ruan, Xudong Wang, Wanli Xu, Mengyi Wang, Peiqiang Chen, Jinmao Chen   +5 more
doaj   +1 more source

A 11 mW 2.4 GHz 0.18 µm CMOS Transceivers for Wireless Sensor Networks

Sensors, 2017
In this paper, a low power transceiver for wireless sensor networks (WSN) is proposed. The system is designed with fully functional blocks including a receiver, a fractional-N frequency synthesizer, and a class-E transmitter, and it is optimized with a ...
Bing Hou, Hua Chen, Zhiyu Wang, Jiongjiong Mo, Junli Chen, Faxin Yu, Wenbo Wang   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

DAB+ Network Implementation in the Czech Republic and Impact of the Audio Coding on Subjective Perception of Sound Quality [PDF]

Radioengineering, 2020
Digital Audio Broadcasting (DAB+) is becoming a reality in the Czech Republic. The first nationwide DAB+ network, based on the regular broadcasting, is being completed.
K. Zyka
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A Novel Bidirectional Wireless Power Transfer System for Mobile Power Application

Applied Sciences, 2019
This paper presents a bidirectional wireless power transfer system for mobile power applications. A novel 2-switch bidirectional wireless power transfer system with dual-side control is proposed for mobile power applications.
Yi-Hung Liao, Yue Lin
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Enhancement of the Excitation Efficiency of the Non-Contact Magnetostrictive Sensor for Pipe Inspection by Adjusting the Alternating Magnetic Field Axial Length

Sensors, 2014
The non-contact magnetostrictive sensor (MsS) has been widely used in the guided wave testing of pipes, cables, and so on. However, it has a disadvantage of low excitation efficiency.
Pengfei Sun, Xinjun Wu, Jiang Xu, Jian Li   +3 more
doaj   +1 more source