Results 71 to 80 of about 621,593 (377)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Implementation of a secure digital chaotic communication scheme on a DSP board [PDF]

, 2010
In this paper, a new a secure communication scheme using chaotic signal for transmitting binary digital signals is proposed and which is then implemented on a Digital Signal Processor (DSP) board.
Aggoune, Woihida, Busawon, Krishna, Ghassemlooy, Zabih, Kharel, Rupak   +3 more
core   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Optimization of Code Rates in SISOME Wiretap Channels

, 2015
We propose a new framework for determining the wiretap code rates of single-input single-output multi-antenna eavesdropper (SISOME) wiretap channels when the capacity of the eavesdropper's channel is not available at the transmitter.
Geraci, Giovanni, Malaney, Robert, Yan, Shihao, Yang, Nan, Yuan, Jinhong   +4 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Enhancement of the Excitation Efficiency of the Non-Contact Magnetostrictive Sensor for Pipe Inspection by Adjusting the Alternating Magnetic Field Axial Length

Sensors, 2014
The non-contact magnetostrictive sensor (MsS) has been widely used in the guided wave testing of pipes, cables, and so on. However, it has a disadvantage of low excitation efficiency.
Pengfei Sun, Xinjun Wu, Jiang Xu, Jian Li   +3 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

The importance of remanufacturing in transmitters production [PDF]

Tehnika, 2015
This paper presents a algorithm for the improvement of the manufacturing process developed and tested for small-scale enterprise. The validity of the algorithm can be seen through: defining basic elements, defining environmental factors, the importance ...
Vorkapić Miloš D., Popović Bogdan M., Poljak Predrag D., Starčević Marko S., Minić Siniša G.   +4 more
doaj   +1 more source

Eight-channel telephone telemetry system [PDF]

, 1973
Portable telemetry system uses conventional telephone link which eliminates mailing or messenger service between physician and analyst. Transmitter is used by physician; receiver is used by analyst.
Carr, T., Smith, R.
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source