Results 71 to 80 of about 3,081,004 (282)

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Ultrathin Amphipathic Dual‐Polymer Networks: Unlocking Hyper‐Permeable CO2 Capture via Solvent‐Mediated Poly(Ethylene Oxide) Amorphization

Advanced Functional Materials, EarlyView.
Hydrophilic PEO‐copolymers and hydrophobic PDMS are physically integrated via a compatibilizing solvent into an amphipathic dual‐polymer network with versatile interfacial affinity and completely amorphized PEO segments for hyper‐permeable CO2 transport.
Ji Wu, Fan Feng, Baiwang Zhao, Jordan Yuan Zhe Ng, Kaiyu Wang, Can Zeng Liang, Guangtai Zheng, Boxuan Zhao, Tai‐Shung Chung, Sui Zhang   +9 more
wiley   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Locally Linearized Solution of Lifting Transonic Flow by Method of Parametric Differentiation

Journal of Mathematical and Fundamental Sciences, 2019
The governing equation of transonic small disturbance flow present a non-linear partial differential equation which is difficult to solve. The method of parametric differentiation reduces the non-linear partial differential equation of transonic flow ...
Harijono Djojodihardjo
doaj  

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Unsteady Aerodynamics of Continuously Morphing Airfoils from Transonic to Hypersonic Regimes

Aerospace
Designing high-speed aircraft for wide-speed-range operation remains a major aerodynamic challenge. This study investigates the unsteady aerodynamics of a continuously morphing airfoil from transonic to hypersonic regimes. A smooth morphing trajectory is
Linyi Zhi, Renqing Zhai, Yu Yang, Xintong Shi, Zhigang Wang   +4 more
doaj   +1 more source

Causes and Solution of Aperiodicity of Supersonic Flow Field Downstream of a Profile Cascade

Communications, 2012
The paper deals with problems of transonic flow field periodicity downstream of a profile cascade with finite number of blades. The origin of phenomena generating this aperiodicity in transonic wind tunnel is described.
Martin Luxa, Jaroslav Synac, Pavel Safarik, David Simurda   +3 more
doaj   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Computational study of cavity flowfield at transonic speeds [PDF]

, 2009
In this paper, the results of a computational study on the unsteady flow features in three-dimensional empty cavities and a cavity with a store are presented.
Khanal, Bidur, Knowles, Kevin, Saddington, A., Saddington, Alistair J., Khanal, B., Alastair Saddington, Bidur Khanal, Knowles, K., Kevin Knowles   +8 more
core   +1 more source