Results 191 to 200 of about 1,283 (268)

Comparison of Hemodynamic Performance, Three-Dimensional Flow Fields, and Turbulence Levels for Three Different Heart Valves at Three Different Hemodynamic Conditions. [PDF]

Ann Biomed Eng
Ferrari L, Obrist D.
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia. [PDF]

Clin Sci (Lond)
Azman Z, Piscopo BR, Sutherland AE, Thiel A, Zahra VA, Pham Y, Nitsos I, Hossain MM, Malhotra A, Miller SL, Bubb KJ, Polglase GR, Allison BJ.   +12 more
europepmc   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

Three-dimensional design, simulation and optimization of a centrifugal compressor impeller with double-splitter blades. [PDF]

Heliyon
Tasharrofi M, Heidarian Shahri M, Madadi A.   +2 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Computational fluid dynamics analysis of aerodynamic characteristics in long-endurance unmanned aerial vehicles. [PDF]

Heliyon
Liao Y, Cheng K, Sun W, Zhao Y, Jia X, Qi W.   +5 more
europepmc   +1 more source

Impact of Cannulation Strategy and Extracorporeal Blood Flow on Recirculation During Veno-Venous Extracorporeal Membrane Oxygenation. [PDF]

Artif Organs
Pooth JS, Förster JK, Benk C, Diel P, Brixius SJ, Maier S, Supady A, Wengenmayer T, Staudacher DL, Haimerl GW, Czerny M, Benk J.   +11 more
europepmc   +1 more source

Accuracy and Performance Evaluation of Low Density Internal and External Flow Predictions using CFD and DSMC. [PDF]

Comput Fluids
Peravali SK, Jafari V, Samanta AK, Küpper J, Amin M, Neumann P, Breuer M.   +6 more
europepmc   +1 more source

Evaluating the role of graft angle on cerebral hemodynamics following direct cerebral bypass for moyamoya disease. [PDF]

PLoS One
Peng C, Church EW, Brindise MC.
europepmc   +1 more source