Results 31 to 40 of about 22,527 (307)

Evolution of transonicity in an accretion disc [PDF]

, 2007
For inviscid, rotational accretion flows driven by a general pseudo-Newtonian potential on to a Schwarzschild black hole, the only possible fixed points are saddle points and centre-type points.
Abraham H, Arnab K Ray, Barceló C Liberati S Visser M, Bondi H, Chakrabarti S K, Das T K Bilić N Dasgupta S, Debnath L, Frank J, Fukue J, Garlick A R, Jayanta K Bhattacharjee, Jordan D W, Kafatos M, Lasota J-P, Lu J F, Matsumoto R, Paczyński B, Pariev V I, Peitz J, Petterson J A, Visser M, Yang R X   +21 more
core   +3 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

On some classes of solutions of aerohydromechanic equations

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
The article gives a review of the method of constructing parametric solutions of polynomial form for systems of partial differential equations and its application to some aerohydromechanic equations.
Yu. A. Kazakova
doaj   +3 more sources

On transonic flow models for optimized design and experiment

EPJ Web of Conferences, 2014
In the paper the near sonic flow theory for flows with small perturbations to sonic parallel flow is developed. This theory stands on the basis of potential flow of a compressible fluid and enables to receive an exact solution of the flow parameters past
Stodůlka Jiří, Sobieczky Helmut
doaj   +1 more source

Endwall aerodynamic losses from turbine components within gas turbine engines

Propulsion and Power Research, 2017
A survey of research on aerodynamic loss investigations for turbine components of gas turbine engines is presented. Experimental and numerically predicted results are presented from investigations undertaken over the past 65 plus years.
Phil Ligrani, Geoffrey Potts, Arshia Fatemi   +2 more
doaj   +1 more source

Skin-Friction-Based Identification of the Critical Lines in a Transonic, High Reynolds Number Flow via Temperature-Sensitive Paint

Sensors, 2021
In this contribution, three methodologies based on temperature-sensitive paint (TSP) data were further developed and applied for the optical determination of the critical locations of flow separation and reattachment in compressible, high Reynolds number
Marco Costantini, Ulrich Henne, Christian Klein, Massimo Miozzi   +3 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source