Results 31 to 40 of about 677 (195)

Safety and Efficacy of Nephron‐Sparing Surgery in Bilateral Wilms Tumors: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Bilateral Wilms tumor (BWT) presents a significant challenge in pediatric oncology, necessitating a delicate balance between achieving oncological control and preserving renal function. While nephron‐sparing surgery (NSS) has emerged as a promising alternative to radical nephrectomy, its overall safety and efficacy profile ...
Menna Sarhan, Yasmine Adel Mohammed, Ayah Abdulgadir, Ibrahim Moqbel, Yehia Nabil Abdalla, Salma Allam, Ahmad Alkheder, Khaled Alsayed Abualkhair   +7 more
wiley   +1 more source

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

Journal of Internal Medicine, Volume 299, Issue 1, Page 126-142, January 2026.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro, Isabel Solares, Daniel Jericó, Francisco J. Castelbón, Javier Tomás Solera, Antoni Riera‐Mestre, María Barreda‐Sánchez, Carlo Poci, Annamaria Nicolli, Francesco Urigo, Ana Sampedro, Rafael Enríquez de Salamanca, Matteo Marcacci, Matías A. Ávila, Pauline Harper, Marta G. Fanlo‐Maresma, Encarna Guillén‐Navarro, Giovanna Graziadei, Andrea Wenzel, Bodo B. Beck, Paolo Ventura, Montserrat Morales‐Conejo, Antonio Fontanellas   +22 more
wiley   +1 more source

Guanidine‐Based Ligands in Bioinorganic Chemistry: Coordination Modes and Applications in Anticancer Metallodrugs

Bioinorganic Chemistry and Applications, Volume 2026, Issue 1, 2026.
Guanidine‐containing molecules represent a versatile class of nitrogen‐rich compounds whose unique structural and physicochemical features underpin a rich and tunable coordination chemistry. Their capacity to act as strong donor ligands, stabilize a variety of metal centers in different oxidation states, and access multiple coordination modes has ...
Almudena del Campo-Balguerías, Alberto Ocaña, Iván Bravo, Carlos Alonso-Moreno, Franc Perdih   +4 more
wiley   +1 more source

Synthesis, spectroscopic characterization, antineoplastic, in vitro-cytotoxic, and antibacterial activities of mononuclear ruthenium(II) complexes

, 2012
The synthesis, antineoplastic, cytotoxic, and antibacterial activities of Ru(II) complexes derived from quinazoline and thiosemicarbazone ligands are reported.
Udugula, Manasa, Yerra, Rajeshwar, De Clercq, Erik, Karki, Subhas Somalingappa, Imran, Mohammad, Balzarini, Jan, Thota, Sreekanth, Kanjarla, Narasimha   +7 more
core   +1 more source

Phytochemical Profiling and Computational Docking Studies Revealing the Potential Anticancer and Antioxidant Properties of Heliotropium indicum L.

Scientifica, Volume 2026, Issue 1, 2026.
This study explores the anticancer and antioxidant potential of Heliotropium indicum L. through integrated phytochemical, biological, and computational approaches. GC–MS analysis identified phenol, 3,5‐bis(1,1‐dimethylethyl) as a major constituent. The chloroform fraction (CHF) exhibited significant in vivo antitumor activity in an Ehrlich ascites ...
Sadia Afroz Shoily, Mst. Shahnaj Parvin, Mohsin Kazi, Aqibul Hasan Aqib, Md. Sabbir Hossain, Rasel Ahmed, Rafat Hossain Rafi, Jaytirmoy Barmon, Mohammad N. Uddin, Md. Ekramul Islam, Muhammad Iqhrammullah   +10 more
wiley   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Immunogenic Study in Antitumor Antibody Production against Transplantable Tumors. Part Ⅰ. Antitumor Antibody in Unadsorbed Immunized Rabbit Sera [PDF]

, 1963
Rabbits were immunized with Ehrlich ascitic tumor cells by intravenous injections or intramuscular injections of Freund's adjuvant. Rabbits were bled periodically, with the antisera being separated from the blood.
Takeda, Kiyoshi
core  

Vitamin‐Engineered Nanoplatforms in Precision Oncology: Integrating Immunotherapy, Delivery Systems, and Theranostics

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Vitamin‐derived nanoplatforms advance precision oncology by augmenting immunotherapy through dendritic cell activation, T‐cell reprogramming, and TME remodeling to enhance antitumor immunity, while enabling targeted therapeutic delivery. These systems integrate theranostic capabilities using vitamin‐conjugated imaging probes for concurrent tumor ...
Ruowa Xu, Yunlong Gao, Hailong Zhang, Zichao Luo   +3 more
wiley   +1 more source

Atividade antitumoral de extratos de bidens pilosa linné ricos em poliacetilenos e de juglona associada ao ascorbato [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2013Introdução. Bidens pilosa L.
Kviecinski, Maicon Roberto
core  

Immune Surveillance and Immune Escape in Cancer: Mechanisms and Immunotherapy

MedComm, Volume 6, Issue 10, October 2025.
Our review focused on how specific cellular subsets crucial for igniting tumor immunity cycle, notably effector and helper T cells alongside antigen presentation cells, interact closely in both antigen‐dependent and ‐independent manners (within centered ring) adjacent to cancer cells.
Ying Peng, Linsheng Zhan, Jianxiang Shi, Jie Wang, Yueying Li, Xiangdong Sun, Jie Lv, Huiyu Yang, Zan Qiu, Xingzhao Liu, Chenyan Li, Shanshan Gong, Wen Jia, Huiying Wang, Yuqi Zhao, Bin Zhang, Wei Guo, Jiancheng Guo, Jian Shang, Qianqian Zhou, Yanan Yang, Feng Gao   +21 more
wiley   +1 more source