Results 131 to 140 of about 548,791 (262)

Exteroceptive Reflexes in Stiff Person Syndrome, Other Neurological Conditions and Healthy Controls

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Stiff person syndrome (SPS) is a rare disabling neurological condition with overlapping symptomatology with more common neurological conditions. Exaggerated exteroceptive reflex mechanisms are thought to play a role in its pathophysiology.
Belinda Cruse, Duncan Wilson, Hugo Morales Briceno, Pamela Garcia, Victor Zhang, Jessica Qiu, Tomas Kalincik, Neil Mahant, Victor Shue Chung Fung   +8 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Percutaneous autologous bone marrow transplantation for the treatment of delayed union of limb bone in children

, 2018
Jun Wu,* Hongxi Guo,* Xing Liu, Ming Li, Yujiang Cao, Xiangyang Qu, Hai Zhou, Liuqi Weng Department of Orthopaedics, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders ...
Liu X, Wu J, Guo HX, Qu XY, Weng LQ, Zhou H, Li M, Cao YJ   +7 more
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Changes of the inflammatory activity and fibrosis in patients with alcoholic liver cirrhosis after autologous hematopoietic stem cell transplantation [PDF]

, 2012
Evaluation of treatment results of chronic liver diseases should be made on the basis of morphological analysis of liver biopsies. The aim of our study was to investigate the effect of autologous hematopoietic stem cell transplantation on histology ...
Kiassov A., Burganova G., Gazizov I., Yilmaz T., Odintcova A., Abdulkhakov S., Gumerova A., Titova M.   +7 more
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Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Autologous non-cultured melanocyte–keratinocyte transplantation in the treatment of vitiligo: patient selection and perspectives

, 2018
Dalia Bassiouny, Samia Esmat Department of Dermatology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt Abstract: Autologous non-cultured melanocyte–keratinocyte transplantation procedure (MKTP) is one of the ...
Bassiouny D, Esmat S
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Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Changes of the inflammatory activity and fibrosis in patients with alcoholic liver cirrhosis after autologous hematopoietic stem cell transplantation

, 2020
Evaluation of treatment results of chronic liver diseases should be made on the basis of morphological analysis of liver biopsies. The aim of our study was to investigate the effect of autologous hematopoietic stem cell transplantation on histology ...
Kiassov A., Burganova G., Gazizov I., Yilmaz T., Odintcova A., Abdulkhakov S., Gumerova A., Titova M.   +7 more
core