Results 201 to 210 of about 1,198,227 (290)

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Feasibility Assessment of Autologous Human Immune System (HIS) ImmunoGraft Platform Development Using Autologous Mobilized Peripheral Blood (MPB) CD34 Cells Derived from Adult HNSCC Patient. [PDF]

Int J Mol Sci
Verma B, Chen GZ, Waller EK, Patel M, Anderson A, Goodwin N, Wesa A, Teng Y, Saba NF.   +8 more
europepmc   +1 more source

Autologous Bone Marrow Transplantation.

Internal Medicine, 1996
openaire   +4 more sources

AML transplantation: autologous vs allogeneic

, 2004
A. Ghavamzadeh, B. Bahar, S. Gholibeikian, F. Safavifar, M. Iravani, M. Jahani   +5 more
semanticscholar   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Tissue Stem Cell-Based Therapies in Parkinson's Disease: A Scoping Review of Therapeutic Mechanisms and Translational Outcomes. [PDF]

Cells
Cueva E, Wiesheu A, Sordo Z, González J, Falconi S, Rodas JA, Leon-Rojas JE.   +6 more
europepmc   +1 more source

Population Pharmacokinetic and Exposure‐Response Analyses of Ibrutinib Combined With Bendamustine and Rituximab in Patients With Mantle Cell Lymphoma

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Efficacy and safety of ibrutinib 560 mg once daily or placebo combined with bendamustine and rituximab (BR) were assessed in patients with mantle cell lymphoma in a randomized phase 3 study (SHINE). The analysis described explores the ibrutinib population pharmacokinetics (PK) and exposure‐response (E‐R) relationships of selected efficacy and ...
Per Olsson Gisleskog, Belén Valenzuela, Nicoline Treijtel, Sanjay Deshpande, Todd Henninger, Juan José Perez‐Ruixo   +5 more
wiley   +1 more source

Human Dermal Microvascular Arterial and Venous Blood Endothelial Cells and Their Use in Bioengineered Dermo‐Epidermal Skin Substitutes

Small Methods, EarlyView.
This study unveils a pioneering approach to bioengineering of human skin substitutes with distinct arterial and venous capillaries. Combining single‐cell transcriptomics and 3D hydrogel models, this work reveals unique endothelial marker dynamics in fetal and juvenile skin.
Dominic Rütsche, Monica Nanni, Phil Cheng, Nicolà Caflisch, Aizhan Tastanova, Céline Jenni, Mitchell P. Levesque, Ueli Moehrlen, Agnes S. Klar, Thomas Biedermann   +9 more
wiley   +1 more source

Intraparenchymal Enzyme Injections in Islet Isolations With Incomplete Ductal Perfusion of Enzymes. [PDF]

Transpl Int
Tol MC, Cornelissen DJ, Chae YS, van der Wel EJ, Sijtsma JC, Doppenberg JB, Vermeulen CJ, Hanegraaf MAJ, van Rossenberg EH, Mieog JSD, Bonsing BA, Huurman VAL, de Koning EJP, Engelse MA.   +13 more
europepmc   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source