Results 61 to 70 of about 85,245 (197)

Synchronous Bilateral Large Renal Cell Carcinoma Treated With Presurgical Pembrolizumab and Lenvatinib Enabling Unilateral Partial Nephrectomy and Dialysis Avoidance: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction Synchronous bilateral renal cell carcinoma is a rare clinical entity that poses considerable challenges in establishing an optimal treatment strategy. Case Presentation A 56‐year‐old woman had synchronous bilateral renal cell carcinoma, with tumors in the right (61 mm) and left (71 mm) kidneys.
Hiroki Kawabata, Shimpei Yamashita, Yuya Iwahashi, Satoshi Muraoka, Takahito Wakamiya, Yasuo Kohjimoto, Isao Hara   +6 more
wiley   +1 more source

RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling

iMeta, EarlyView.
This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou, Weifeng Hong, Songhua Cai, Dandan Guo, Zhiping Yan, Jinyu Zhu, Yang Shen, Juncheng Wan, Xudong Qu, Wen Zhang, Runkang Zhao, Zhao Xie, Zhongji Chen, Tong Jiang, Yaling Lin, Wenlong Jia, Ling Wang, Zhao Huang, Xuexin Li, Bufu Tang   +19 more
wiley   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Efficacy of soft tissue augmentation in the maxillary esthetic region: A 5‐year randomized controlled trial

Journal of Periodontology, EarlyView.
Abstract Background Soft tissue grafting at dental implant sites has been proposed to enhance esthetic outcomes. A xenogeneic collagen matrix (XCM) was introduced as an alternative grafting material to connective tissue. Only short‐term results are yet available.
Elise G. Zuiderveld, Gerry M. Raghoebar, Arjan Vissink, Barzi Gareb, Henny J. A. Meijer   +4 more
wiley   +1 more source

Digestive autoimmune diseases mimicking gastrointestinal manifestations in children with sickle cell anemia: A report of three cases

JPGN Reports, EarlyView.
ABSTRACT Sickle cell anemia (SCA) is a genetic disorder that presents with a variety of systemic complications, including gastrointestinal (GI) manifestations. These GI symptoms can overlap with those of digestive autoimmune diseases (DAD) such as inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH), complicating the diagnosis and management.
Saray Mesonero Cavia, Marta García Bernal, Maria Jose López Liñan, Roger García Puig   +3 more
wiley   +1 more source

Post‐operative joint stiffness after Bereiter trochleoplasty does not affect 2‐year improvement in patient‐reported outcomes. A prospective cohort study of 374 Bereiter trochleoplasties

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Bereiter trochleoplasty (TP) is a well‐described procedure to address trochlear dysplasia (TD). Post‐operative joint stiffness with reduced range of motion (ROM) is a common complication usually requiring arthroscopically assisted manipulation (AAM) with the removal of adhesions and scar tissue. Inferior clinical outcomes after TP have
Christian Dippmann, Christos Soleas, Anke Simone Rechter, Volkert Siersma, Kristoffer Weisskirchner Barfod, Peter Lavard   +5 more
wiley   +1 more source

Safety of autologous nucleus pulposus cell transplantation with fibrin glue following endoscopic discectomy in chronic low back pain: a preliminary phase I trial. [PDF]

BMC Musculoskelet Disord
Sadri B, Labibzadeh N, Madani H, Maal AB, Niknejadi M, Hossein-Khannazer N, Farzanbakhsh S, Karimi S, Hassanzadeh M, Bagherifard A, Emadedin M, Vosough M.   +11 more
europepmc   +1 more source

Very low dislocation rate and good clinical outcome after Bereiter trochleoplasty and additional procedures following the Copenhagen patella–femoral instability algorithm: One‐ and two‐years outcomes from a consecutive cohort of 368 cases

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Patello–femoral instability (PFI) is often caused by predisposing factors, with trochlea dysplasia (TD) as the most prominent. Untreated patellar instability leads to impaired function and an increased risk of patellofemoral osteoarthritis.
Christian Dippmann, Volkert Siersma, Simone Rechter, Kristoffer W. Barfod, Peter Lavard   +4 more
wiley   +1 more source

Advancements and trends in digestive system autotransplantation: a bibliometric and visualization analysis. [PDF]

Front Med (Lausanne)
Abulaiti A, Tuergan T, Tulahong A, Zhang R, Shao Y, Aji T.   +5 more
europepmc   +1 more source

Prior procedures, graft location, preoperative physical health, postoperative strength and graft integrity are associated with 10‐year clinical outcome after matrix‐induced autologous chondrocyte implantation

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
ABSTRACT Purpose To investigate factors associated with 10‐year clinical scores after matrix‐induced autologous chondrocyte implantation (MACI). Methods This retrospective case series included 143 MACI patients with 10‐year clinical and radiological follow‐up.
Jay R. Ebert, Peter K. Edwards, Sven Klinken, David J. Wood, Gregory C. Janes   +4 more
wiley   +1 more source