Results 111 to 120 of about 76,294 (297)

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Recuperación hematopoyética en el trasplante alogénico de médula ósea Hematopoietic recovery in the allogeneic bone marrow transplantation

Revista Cubana de Hematología, Inmunología y Hemoterapia, 1999
Se evaluaron 19 pacientes con enfermedades hematológicas a los que se les realizó trasplante de médula alogénico. En 18 pacientes el donante fue un hermano HLA idéntico y en 1 caso un hermano haploidéntico. La edad media fue de 28,3 años.
Elvira Dorticós Balea, Carmen V Díaz Durán, Marianela Estrada del Cueto, José Carnot Uría, Alejandro González Otero, Valia Pavón Morán   +5 more
doaj  

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Transplantation tolerance, microchimerism, and the two-way paradigm [PDF]

, 1998
Demetris, AJ, Starzl, TE
core   +1 more source

The use of transgenic animals for xenotransplantation: An update

Animal Models and Experimental Medicine, EarlyView.
One way to produce genetically modified pigs is to use somatic cell nuclear transfer (SCNT). This procedure involves removing the metaphase plate from a mature oocyte using micromanipulation and then transferring the modified nucleus from the donor somatic cell to the oocyte.
Julia Motławska, Ana Amaral, Marta Cerveira‐Pinto, Paweł Kordowitzki   +3 more
wiley   +1 more source

Surgery: Art or science? Birth of organ transplantation [PDF]

, 1998
Billingham, Billingham, Burnet, Calne, Carrel, Daston, Dausset, Dempster, Dubost, Gibson, Groth, Hamburger, Hamburger, Hau, Holman, Holton, Jaboulay, Küss, Küss, küss, Kœstler, Lawrence, Mathé, Medawar, Merrill, Merrill, Michon, Mitchison, Morgan, Murray, Servelle, Starzl, Starzl, Starzl, Starzl, T.E. Starzl, Unger, Voronoy Yu   +37 more
core   +1 more source

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Transplantation of the homologous canine heart

Journal of Thoracic Surgery, 1957
S F, SAYEGH, O, CREECH
openaire   +2 more sources

Radiation emergency medical countermeasures: Current formulary, identified gaps, and future approaches

Animal Models and Experimental Medicine, EarlyView.
Current radiation medical countermeasures primarily focus on hematopoietic acute radiation syndrome (H‐ARS) using agents like granulocyte colony‐stimulating factor (G‐CSF), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), and romiplostim, alongside treatments for internal contamination (Prussian blue, diethylenetriamine pentaacetate [DTPA ...
Wen‐Bing Ma, Rong‐Hua Yin, Guang‐Ming Ren, Yin Zhang, Li‐Juan Li, Wei Liu, Ting Chen, Wei Zhou, Mian Zu, Rong‐Ling Yin, Xin‐Di Shi, Lei Wang, Xiao‐Ming Yang   +12 more
wiley   +1 more source