British Journal of Haematology, EarlyView.Inherited thrombocytopenia (IT) caused by germline variants in RUNX1, ETV6 or ANKRD26 carries a high risk of developing haematological malignancy. This study examined the clinical, platelet and molecular characteristics of 66 patients with these conditions, who carried 24 distinct genetic variants in the corresponding genes.
Ana Marín‐Quílez +34 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Multiple myeloma (MM) is a clonal malignancy of plasma cells characterized by frequent relapse and therapeutic resistance. G protein‐coupled receptor class C group 5 member D (GPRC5D) has emerged as a promising immunotherapeutic target due to its high and selective expression in MM cells and minimal presence in normal tissues.
Xueting Wang +3 more
wiley +1 more source
Transcriptome profiling of prostatic tumours from ENACT trial patients with or without enzalutamide
BJU International, EarlyView.Objectives To evaluate the longitudinal transcriptomic changes that occurred over time in patients from the ENACT trial (ClinicalTrials.gov identifier: NCT02799745). ENACT evaluated patients with low‐ or intermediate‐risk prostate cancer, comparing the efficacy and safety of enzalutamide plus active surveillance (AS) to AS alone.
Nicole Handa +12 more
wiley +1 more source
New Trends in SARS-CoV-2 Variants and Vaccines. [PDF]
Vaccines (Basel)Khor SS.
europepmc +1 more source
Beyond synapses: cytoplasmic connections in brain function and evolution
Biological Reviews, EarlyView.ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley +1 more source
Assessment of Fresh Homologous Osteochondral Transplantation in Knees as a Salvage Treatment: A Prospective Case Series with a Minimum Follow-up Period of 10 Months. [PDF]
Rev Bras Ortop (Sao Paulo)Gracitelli G +5 more
europepmc +1 more source
Re‐make, re‐model: evolution and development of vertebrate cranial lateral lines
Biological Reviews, EarlyView.ABSTRACT Lateral lines are placodally derived mechanosensory systems on the heads and trunks of many aquatic vertebrates. There is evidence of lateral lines in the earliest known vertebrate fossils, and they exist in organisms with widely different craniofacial morphologies – including the presence or absence of jaws, external or internal nostrils, and
Vishruth Venkataraman +3 more
wiley +1 more source
Clinical Genetics, EarlyView.Our mouse model with a c.259G>A transition in PRPS1 showed a significant decrease in the number of hair cells and SGN counts at 48 weeks of age and a reduction in Prps1 enzymatic activity in the KI mouse. This model will serve as a valuable tool for developing therapeutic strategies.
Denise Yan +6 more
wiley +1 more source
Evaluation of the correlation between six scoring systems for assessing the severity of end-stage liver disease and intraoperative blood loss during liver transplantation: a retrospective study. [PDF]
Clin Transplant ResMajeed A +8 more
europepmc +1 more source
Skin‐Derived PGD2 Promotes Antigen‐Specific IgE Production via CRTH2 Signaling
Allergy, EarlyView.
Misato Kida +5 more
wiley +1 more source