Results 151 to 160 of about 76,294 (297)

Milestones in Transplantation: The Story so Far [PDF]

, 2001
Starzl, TE
core  

Modeling Protein–Protein and Protein–Ligand Interactions by the ClusPro Team in CASP16

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT In the CASP16 experiment, our team employed hybrid computational strategies to predict both protein–protein and protein–ligand complex structures. For protein–protein docking, we combined physics‐based sampling—using ClusPro FFT docking and molecular dynamics—with AlphaFold (AF)‐based sampling, followed by AF‐based refinement.
Ryota Ashizawa, Sergei Kotelnikov, Omeir Khan, Stan Xiaogang Li, Ernest Glukhov, Xin Cao, Maria Lazou, Ayse Bekar‐Cesaretli, Derara Hailegeorgis, Veranika Averkava, Yimin Zhu, George Jones, Hao Yu, Dmytro Kalitin, Darya Stepanenko, Kushal Koirala, Taras Patsahan, Dmitri Beglov, Mark Lukin, Diane Joseph‐McCarthy, Carlos Simmerling, Alexander Tropsha, Evangelos Coutsias, Ken A. Dill, Dzmitry Padhorny, Sandor Vajda, Dima Kozakov   +26 more
wiley   +1 more source

KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma. [PDF]

Signal Transduct Target Ther
Wu J, Yuan J, Liu Z, Zhou Y, Zhang B, Xu Y, Zeng Q, Wu Z, Kong L, Wang J, Zhang B, Yang J, Lv T, Shi Y, Yang J.   +14 more
europepmc   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

RNA m5C methylation in cancer: mechanisms and biological impact. [PDF]

Oncogenesis
Guan Z, Li W, He Y, Guo W.
europepmc   +1 more source

Principles of transplantation [PDF]

, 1998
Reyes, J, Starzl,
core  

Organoid‐based novel technology for antitumor drug screening

VIEW, EarlyView.
Organoids represent a cutting‐edge research model that closely mimics in vivo organ physiology, making them highly valuable for tumor immunotherapy drug screening. This review explores the integration of organoids with advanced technologies, such as gene editing, 3D bioprinting, and AI, highlighting novel fusion platforms and their applications.
Yu Su, Yuan Chen, Guanning Wei, Yihai Shi   +3 more
wiley   +1 more source

Multifunctional antimicrobial peptide‐containing electrospun nanofibrous dressings for accelerating wound healing with exposed bone

VIEW, EarlyView.
(a) Schematic representation of the chemical cross‐linking of PVB/PCL‐TiO2‐RegIIIγ electrospun nanofibers. (b) Schematic illustration of the biomimetic dressing promoting healing in an exposed bone wound. The treatment of wounds with exposed bone has always been a difficult problem in the clinical treatment of orthopedics.
Chenhao Gong, Xuewei Fu, Peng Wang, Hui Zhao, Cheng Wang, Wuyi Zhou, Yuanjun Xia   +6 more
wiley   +1 more source

Stem Cell Transplantation for Ovarian Cancer Patient with Associated Myelodysplasia After Maintenance Therapy with Olaparib: A Case Report. [PDF]

Int Med Case Rep J
Linn Z, Gu Z, Wang L, Cai S.
europepmc   +1 more source

Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems

VIEW, EarlyView.
A bionic nanomedicine system with core–shell structure (Nm‐pAu/CP/KU) was constructed. PEGylated gold nanoparticles (pAu) were loaded with cisplatin (CP) and a radiochemotherapy sensitizer (KU‐60019) to form the core pAu/CP/KU, and homologous nasopharyngeal carcinoma cell membrane vesicles (Nm) were used as the shell.
Junhua Zhang, Xinying Xiang, Xinmin Nie, Jian Li, Rong Gui   +4 more
wiley   +1 more source