Results 171 to 180 of about 76,294 (297)

Comprehensive Colorectal Cancer Stem Cell Transcriptomic Signatures That Can Predict Patient Prognostic Outcomes

open access: yesCancer Science, EarlyView.
We characterized colorectal cancer stem‐like cell (CRC‐SC)–derived transcriptomic subtypes based on mRNA expression of 57 patient‐derived SC lines. Expression profiles were compared with normal colonic epithelium stem‐like cells (NCE‐SCs), yielding differentially expressed genes.
Fumihiko Kakizaki   +13 more
wiley   +1 more source

TGM2 Regulates Radiosensitivity via POGZ‐Mediated Repair of DNA Double‐Strand Breaks in Cervical Cancer

open access: yesCancer Science, EarlyView.
The present study revealed for the first time that TGM2 could regulate the radiosensitivity of cervical cancer via POGZ‐mediated DNA DSB repair. Our findings revealed that TGM2 regulates the radiosensitivity of cervical cancer and demonstrated that POGZ serves as a bridge linking TGM2 to the DNA damage repair process, and suggested a novel mechanistic ...
Yunbo Chi   +5 more
wiley   +1 more source

Crucial Contribution of BACH1 to Bladder Cancer Progression via Upregulating Epithelial‐Mesenchymal Transition Pathway

open access: yesCancer Science, EarlyView.
BACH1 is associated with poor prognosis in BC patients and plays a critical role in promoting tumor progression and metastasis. Furthermore, we elucidated the mechanism by which BACH1 facilitates tumor progression and metastasis, primarily through activation of the EMT pathway. These findings suggest that BACH1 may serve as a novel prognostic biomarker
Tomoya Hatayama   +19 more
wiley   +1 more source

YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice

open access: yesCell Proliferation, EarlyView.
Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen   +8 more
wiley   +1 more source

Association of Homologous Recombination Repair Alterations with Outcomes in Patients with Metastatic Hormone-Sensitive Prostate Cancer. [PDF]

open access: yesClin Cancer Res
Hage Chehade C   +11 more
europepmc   +1 more source

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