Results 241 to 250 of about 73,189 (295)

Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent

eFood, Volume 6, Issue 4, August 2025.
Fucoidan, a bioactive polysaccharide from brown algae, inhibits receptor tyrosine kinase (RTK) activation and vascular endothelial growth factor (VEGF) signaling, suppressing the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and RAS/RAF/mitogen‐activated protein kinase/extracellular signal‐regulated kinase ...
Muhammad Umer Khan, Iqra Khurram, Maha Munir, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +7 more
wiley   +1 more source

Allele-Selective Genome Editing of the Human Leukocyte Antigen Locus in Human Dental Pulp Cells Using Zinc Finger Nucleases. [PDF]

Cureus
Kuroda I, Kawaguchi T, Chikusa S, Ishii S, Aoki H, Motohashi T, Kunisada T, Osawa M, Tezuka KI.   +8 more
europepmc   +1 more source

Next Generation Sequencing Allows Identification of a Novel Mutation in the TfR2 Gene and Outperforms the Conventional Diagnostic Techniques

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Introduction Type 3 hereditary hemochromatosis (HH) is a rare genetic disease due to mutations in the transferrin receptor 2 (TFR2) gene. Methods and Results Here, we describe the case of an Italian patient presenting with hyperferritinemia and hepatic iron accumulation, not evidenced by magnetic resonance imaging, that was subsequently ...
Miriam Longo, Erika Paolini, Marica Meroni, Felice Cinque, Cristina Bertelli, Giuseppina Pisano, Marco Maggioni, Anna Ludovica Fracanzani, Rosa Lombardi, Paola Dongiovanni   +9 more
wiley   +1 more source

Impact of posttransplant cyclophosphamide-based GVHD prophylaxis in patients 70 years and older: an update from BMT CTN 1703. [PDF]

Blood Adv
Abedin S, Martens MJ, Bolaños-Meade J, Al Malki MM, Lian Q, Runaas L, Elmariah H, Gooptu M, Larkin KT, Shaffer BC, Loren AW, Solh M, Alousi AM, Jamy OH, Perales MA, Rezvani A, Bhatt A, El Jurdi N, Yao JM, Applegate K, Kean LS, Efebera YA, Reshef R, Clark W, Leifer E, Saber W, Horowitz MM, Jones RJ, Holtan SG, Hamadani M.   +29 more
europepmc   +1 more source

Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1330-1348, August 2025.
ABSTRACT Microglia, the resident immune‐competent cells of the brain, become dysfunctional in Alzheimer's disease (AD), and their aberrant immune responses contribute to the accumulation of pathological proteins and neuronal injury. Genetic studies implicate microglia in the development of AD, prompting interest in developing immunomodulatory therapies
Madison K. Kuhn, Elizabeth A. Proctor
wiley   +1 more source

Allogeneic, Xenogeneic, and Exogenic Hearts for Transplantation. [PDF]

Methodist Debakey Cardiovasc J
Garry DJ, Garry MG, Nakauchi H, Masaki H, Sachs DH, Weiner JI, Reichart D, Wolf E.   +7 more
europepmc   +1 more source

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

Faecalibacterium prausnitzii prevents age-related heart failure by suppressing ferroptosis in cardiomyocytes through butyrate-mediated LCN2 regulation. [PDF]

Gut Microbes
Zhang Y, Wei Y, Han X, Shi L, Yu H, Ji X, Gao Y, Gao Q, Zhang L, Duan Y, Li W, Yuan Y, Shi J, Cheng L, Li Y.   +14 more
europepmc   +1 more source

Terasaki's seminal contributions in HLA and Organ Transplantation [PDF]

, 1999
Starzl, TE
core  

Ontogeny and organ‐specific steroidal glycoside diversity is associated with differential expression of steroidal glycoside pathway genes in two Solanum dulcamara leaf chemotypes

Plant Biology, Volume 27, Issue 5, Page 651-668, August 2025.
Steroidal glycoside diversity among organs across ontogeny in relation to candidate gene expression in two Solanum dulcamara chemotypes. Abstract Solanaceous plants, such as Solanum dulcamara, produce steroidal glycosides (SGs). Leaf SG profiles vary among S.
R. A. Anaia, I. Chiocchio, R. Sontowski, B. Swinkels, F. Vergara, N. M. van Dam   +5 more
wiley   +1 more source