Results 71 to 80 of about 3,035,750 (346)

Coronavirus disease 2019: Implications of emerging infections for transplantation

American Journal of Transplantation, 2020
The recent identification of an outbreak of 2019‐ novel Coronavirus is currently evolving, and the impact on transplantation is unknown. However, it is imperative that we anticipate the potential impact on the transplant community in order to avert ...
M. Michaels, R. L. La Hoz, Lara Danziger Isakov, E. Blumberg, Deepali Kumar, Michael Green, T. Pruett, C. Wolfe   +7 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Deconstructing Neurogenesis, Transplantation and Genome-Editing as Neural Repair Strategies in Brain Disease

Frontiers in Cell and Developmental Biology, 2020
Neural repair in injury and disease presents a pressing unmet need in regenerative medicine. Due to the intrinsically reduced ability of the brain to replace lost and damaged neurons, reversing long-term cognitive and functional impairments poses a ...
Muhammad O. Chohan, Muhammad O. Chohan
doaj   +1 more source

Transplantation in children [PDF]

, 1976
Kidney transplantation in very young children, less than 2 years of age, has usually failed, mainly because of difficulties maintaining these patients on hemodialysis long enough to permit retransplantation after loss of the original graft.
Charles W. Putnam, DeShazo, Kendrick A. Porter, Lilly, Lilly, Richard Weil, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl   +15 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The role of IgM-enriched intravenous immunoglobulin in transplantation [PDF]

Sanamed, 2014
After organ transplantation, gamma globulin and intravenous immunoglobulin enriched with IgM are most frequently used in septic shock as early immune-support.
Szabó Judit, Smudla Anikó, Fazakas János   +2 more
doaj   +1 more source

Liver transplantation: an unfinished product. [PDF]

, 1989
Liver transplantation has become an extraordinarily valuable and useful operation, but one that is not perfect and that has not been exploited to anything like its full potential.
Concepcion, W, Gordon, RD, Iwatsuki, S, Makowka, L, Podesta, L, Starzl, TE, Stieber, A, Todo, S, Tzakis, AG, Yanaga, K   +9 more
core  

Kidney after nonrenal transplantation-the impact of alemtuzumab induction [PDF]

, 2009
BACKGROUND.: Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to end-stage renal disease and the need for kidney transplantation. We sought to evaluate the role of alemtuzumab induction in this population.
Amit Basu, Calne, Claire Morgan, Deanna Blisard, Demetrius Ellis, Eghtesad, Geoffrey Kurland, George Mazariegos, Henkie P. Tan, Igor Dvorchik, J Wallis Marsh, Jerry McCauley, Kareem Abu-Elmagd, Kenneth R. McCurry, Kirk, Knechtle, Ojo, Parmjeet S. Randhawa, Ron Shapiro, Shapiro, Shapiro, Shapiro, Steven Webber, Stuart, Tan, Thomas E. Starzl, Vivek Sharma, Waldmann   +27 more
core   +1 more source

The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy

Bone Marrow Transplantation, 2020
The new coronavirus SARS-CoV-2 has rapidly spread over the world causing the disease by WHO called COVID-19. This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell ...
P. Ljungman, M. Mikulska, R. de la Cámara, G. Basak, C. Chabannon, S. Corbacioglu, R. Duarte, H. Dolstra, A. Lankester, M. Mohty, S. Montoto, J. Murray, R. Peffault de Latour, J. Snowden, I. Yakoub-Agha, B. Verhoeven, N. Kröger, J. Styczyński   +17 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source