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Current Opinion in Nephrology and Hypertension, 1995
The success of transplantation is such that it is now the treatment of choice for many of those requiring renal replacement therapy. The use of other solid organs, including liver, pancreas, heart and lung, continues to progress. This article reviews some recent advances in our understanding of the immunological response to alloantigen and xenoantigen.
S T, Ball, M J, Dallman
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The success of transplantation is such that it is now the treatment of choice for many of those requiring renal replacement therapy. The use of other solid organs, including liver, pancreas, heart and lung, continues to progress. This article reviews some recent advances in our understanding of the immunological response to alloantigen and xenoantigen.
S T, Ball, M J, Dallman
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Immunogenetics and immunology in transplantation
Immunologic Research, 2010Advances in immunogenetics and histocompatibility have facilitated the clinical transplantation of solid organs and tissues. Improved definition of HLA antigens, alleles, and haplotypes has clarified the diversity of the HLA system among different racial/ethnic populations.
Andrea A, Zachary +3 more
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Journal of Pediatric Surgery, 2003
The immune response to an allogeneic transplanted organ is T-cell dependent. It is governed partially by the context in which the T-cell encounters the antigen and can range from apoptosis, anergy, and neglect to full activation. The current armamentarium of immunosuppressive agents acts to inhibit the various steps of this T-cell activation pathway ...
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The immune response to an allogeneic transplanted organ is T-cell dependent. It is governed partially by the context in which the T-cell encounters the antigen and can range from apoptosis, anergy, and neglect to full activation. The current armamentarium of immunosuppressive agents acts to inhibit the various steps of this T-cell activation pathway ...
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IMMUNOLOGIC CONSEQUENCES OF TRANSPLANTATION
Chest Surgery Clinics of North America, 1995With current immunosuppressive regimens, rejection is common after lung transplantation. Acute rejection is usually easily reversible with therapy, but chronic rejection often responds poorly and is the leading cause of late morbidity and mortality. Although the pathogenesis of chronic rejection is not fully understood and might be different from ACR ...
R J, Keenan, A, Zeevi
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Basic Transplantation Immunology
Surgical Clinics of North America, 2006Humans are protected from a daily onslaught of pathogenic organisms by an immune system that provides multiple layers of protection. Until solid organ transplantation became technically feasible in the early twentieth century, this constant state of surveillance for foreign cells that are associated with the immune response mostly was viewed as ...
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The immunological background to transplantation
Journal of Antimicrobial Chemotherapy, 1995Organs are transplanted clinically to rectify an irreversible functional deficit but, unless donor and recipient are genetically identical, graft antigens will trigger a rejection response by the recipient. In the early part of this century, experiments on transplantation of tumours showed that there were strict limitations on the ability of tumour ...
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Advances in transplantation immunology
The Japanese Journal of Surgery, 1987Although there have been dramatic advances in clinical organ transplantation over the past 20 years, rejection, both acute and chronic, and the complications of immunosuppression remain major problems. Nevertheless as our understanding of the immune response to a vascularized organ allograft develops, so too will our ability to develop more specific ...
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In this Issue: Transplant Immunology and Transplant Biology
International Reviews of Immunology, 2014Transplantation faces an unprecedented shortage of organs available for transplantation, resulting in longer waiting times and transplant candidates on the waiting list dying before getting a transplant. This dramatic situation triggered the search for new approaches and innovations to increase the donor pool, such as extending the acceptance criteria ...
Lucian P, Jiga, Mihai, Oltean
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Anaesthesia & Intensive Care Medicine, 2009
Understanding the interaction of foreign tissue with the recipient immune system is key to improving results from organ transplantation. Responses are mediated by the humoral and cellular arms of the host immune system towards the tissues of the transplant. Unchecked this can lead to rejection of the graft.
Cota, Allwyn M., Midwinter, Mark J.
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Understanding the interaction of foreign tissue with the recipient immune system is key to improving results from organ transplantation. Responses are mediated by the humoral and cellular arms of the host immune system towards the tissues of the transplant. Unchecked this can lead to rejection of the graft.
Cota, Allwyn M., Midwinter, Mark J.
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