Results 111 to 120 of about 300,620 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Validation of a deterministic linear Boltzmann transport equation solver for rapid CT dose computation using physical dose measurements in pediatric phantoms. [PDF]

Med Phys, 2021
Principi S, Lu Y, Liu Y, Wang A, Maslowski A, Wareing T, Van Heteren J, Schmidt TG.   +7 more
europepmc   +1 more source

Generalized Transport Equation

, 2015
A transport equation for the density operator of the Landau quasiparticle in the presence of a constant magnetic field is derived using the generalized self-consistent field (GSCF) method.
Vasconcellos A.R., Luzzi R., LUZZI, R, VASCONCE.AR   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Solvability of a Two Dimensional Coefficient Inverse Problem for Transport Equation and a Numerical Method

, 2011
In this article we present the solvability of an overdetermined coefficient inverse problem for planar transport equation with no scattering. To compute the approximate solution of the problem we propose a numerical method by using centered difference ...
Zekeriya Ustaoglu, Arif Amirov, Bayram Heydarov   +2 more
core   +1 more source

Topics in Core-Collapse Supernova Theory: The Formation of Black Holes and the Transport of Neutrinos [PDF]

, 2012
Core-Collapse Supernovae are one of the most complex astrophysical systems in the universe. They deeply entwine aspects of physics and astrophysics that are rarely side by side in nature.
O'Connor, Evan Patrick
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Application of a Transition Transport Model to Industrially Relevant Aerodynamic Configurations

, 2011
The correlation-based γ-Reθt transition transport model has been implemented into a hybrid Reynolds-Averaged Navier-Stokes solver and evaluated on various basic test cases.
Seyfert, Cornelia
core  

Higher-order approximation of contaminant transport equation for turbulent channel flows based on centre manifolds and its numerical solution

, 2015
The contaminant transport process governed by the advection–diffusion equation plays an important role in modelling industrial and environmental flows.
Ngo-Cong, D., Strunin, D. V., Skvortsov, A. T., Mai-Duy, N., Mohammed, F. J., Tran-Cong, T.   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source