Results 71 to 80 of about 300,620 (314)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Implementation of a Second-Order TVD Transport Algorithm in the General Ocean Model (GOM)
Journal of Marine Science and EngineeringThis study presents the implementation of a scalar transport algorithm in the recently developed General Ocean Model (GOM), a three-dimensional, unstructured grid, finite volume/finite difference model.
Jungwoo Lee +3 more
doaj +1 more source
, 2007 In this work a practical scheme is developed for the first-principles study of time-dependent quantum transport. The basic idea is to combine the transport master equation with the well-known time-dependent density functional theory.
yan@ust.hk +5 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Saturation and linear transport equation [PDF]
Physics Letters B, 2009 We show that the GBW saturation model provides an exact solution to the one dimensional linear transport equation. We also show that it is motivated by the BK equation considered in the saturated regime when the diffusion and the splitting term in the diffusive approximation are balanced by the nonlinear term.
openaire +4 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Covariant transport equation and gravito-conductivity in generic stationary spacetimes
European Physical Journal C: Particles and Fields, 2022 We find a near detailed balance solution to the relativistic Boltzmann equation under the relaxation time approximation with a collision term which differs from the Anderson–Witting model and is dependent on the stationary observer.
Song Liu, Xin Hao, Shaofan Liu, Liu Zhao
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Analytical Solutions for Spatially Variable Transport-Dispersion of Non-Conservative Pollutants [PDF]
Journal of Heat and Mass Transfer Research, 2019 Analytical solutions have been obtained for both conservative and non-conservative forms of one-dimensional transport and transport-dispersion equations applicable for pollution as a result of a non-conservative pollutant-disposal in an open channel with
Vidya Prasad Shukla
doaj +1 more source