Results 111 to 120 of about 3,937,333 (327)

Infrastructures Impacts Assessment, deliverable 4 [PDF]

The objective of the report is to produce qualitative analysis of the evolution of the transport system after important infrastructure investment project, and also to produce quantitative indicators.
Charles Raux, Jean-Michel Cusset, Patrick Bonnel, Romain Petiot   +3 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The limits of technology: achieving transport efficiency in developing nations [PDF]

, 2004
Emissions from the transport sector represent the fastest growing source of greenhouse gas emissions. There is little prospect that this situation will be resolved with a single technological fix. As developing nations quickly move to catch up with the
Wright, Lloyd
core  

Computational Method for Phase Space Transport with Applications to Lobe Dynamics and Rate of Escape

, 2017
Lobe dynamics and escape from a potential well are general frameworks introduced to study phase space transport in chaotic dynamical systems. While the former approach studies how regions of phase space are transported by reducing the flow to a two ...
A.M. Mancho, B. Maelfeyt, B. Sandstede, C. C. Martens, C. Jaffé, C. Jaffé, D. Babyuk, D. Beigie, D. Beigie, D. G. Dritschel, E. E. Zotos, E. E. Zotos, F. A. McRobie, F. Lekien, Francois Lekien, H. Aref, H. Aref, J. Duan, J. O’Rourke, J.M.T. Thompson, K. A. Mitchell, K. A. Mitchell, K. A. Mitchell, M. Dellnitz, M. I. Shamos, M. Toda, M.A. Sepulveda, R. Barrio, R. E. Gillilan, R. S. Mackay, S. Balasuriya, S. Balasuriya, S. Balasuriya, S. Wiggins, S. Wiggins, Sh. D. Ross, Sh. Naik, Shane D. Ross, Shibabrat Naik, V. Rom-Kedar, V. Rom-Kedar, V. Rom-Kedar, W. S. Koon, W. S. Koon, W. S. Koon   +44 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Muon simulation codes MUSIC and MUSUN for underground physics

, 2008
The paper describes two Monte Carlo codes dedicated to muon simulations: MUSIC (MUon SImulation Code) and MUSUN (MUon Simulations UNderground). MUSIC is a package for muon transport through matter.
Abramowicz, Abramowicz, Aglietta, Aglietta, Aglietta, Aglietta, Agostinelli, Alvarez, Ambrosio, Ambrosio, Andreev, Andres, Antonioli, Araújo, Araújo, Belolaptikov, Bezrukov, Bezrukov, Bugaev, Caffau, Carson, Carson, Chirkin, Dar, Dutta, Fassò, Formaggio, Gaisser, Kelner, Kelner, Kudryavtsev, Kudryavtsev, Kudryavtsev, Kudryavtsev, Lindote, Lipari, Rossi, Schultz, Sokalski, Tang, V.A. Kudryavtsev, van Ginneken, Wang, Wulandari   +43 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

European air transport public service obligations: a periodic review [PDF]

The ‘Third Package’ of European Union air transport liberalisation measures came into effect on 1 January 1993 and has substantially reduced the restrictions on interstate flight operations.
Aisling Reynolds-Feighan
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Demonstration of a nonlinear dynamic model of traffic flow planning in intelligent transport systems [PDF]

E3S Web of Conferences
The significant relevance of the problems of traffic flow planning in intelligent transport systems is pointed out, with a critical analysis of previous scientific studies on this issue.
Lytvynenko Sergiy, Desiatko Alona, Kotov Vladyslav, Liubyi Yevhen, Shelekhan Hanna, Voitsehovskiy Viktor   +5 more
doaj   +1 more source