Results 171 to 180 of about 871,856 (304)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Effect of Glass Fibers on the Mechanical and Transport Properties of Polymer Inclusion Membranes Composed of Aliquat 336 and PVDF-HFP. [PDF]

Membranes (Basel)
Kukoc L, Velikova K, Perinovic-Jozic S, Biocic M, Gateshki M, Kolev SD, Spassov TG.   +6 more
europepmc   +1 more source

Cluster Analysis as a Tool for Quantifying Structure-Transport Properties in Simulations of Superconcentrated Electrolyte

Using molecular dynamics simulations and graph-theory-based cluster analysis, we investigate the structure-transport properties of typical water-in-salt electrolytes.
Sheng, Bi, Mathieu, Salanne
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Impact of Surface Treatments on the Transport Properties of Germanium 2DHGs. [PDF]

ACS Appl Electron Mater
Sangwan N, Jutzi E, Olsen C, Vogel S, Nigro A, Zardo I, Hofmann A.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Thermodynamic and Transport Properties of Alkanes (C_nH_2n+2; n = 5-8). [PDF]

ChemistryOpen
Awasthi D, Gautam N, Khanal SP, Koirala RP, Adhikari NP.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Microstructure and Transport Properties of CaCl₂-CaI₂ Molten Salt: A First-Principles Molecular Dynamics Study. [PDF]

Materials (Basel)
Chen M, Zhu L, Yan D, Kong L, Yang B.
europepmc   +1 more source

Charge transport and excited states in organic semiconductors

, 2011
PhDOrganic semiconductors are of increasing technological interest in applications such as light emitting diodes, field effect transistors, and photovoltaic devices In order to reveal the basic principles behind these organic semiconductors, charge ...
Song, Jingyao
core