Results 1 to 10 of about 1,765,806 (356)

Protein transport into mitochondria [PDF]

Current Opinion in Microbiology, 1987
Mitochondria are made up of two membrane systems that subdivide this organelle into two aqueous subcompartments: the matrix, which is enclosed by the inner membrane, and the intermembrane space, which is located between the inner and the outer membrane.
Hartl, Franz-Ulrich, Neupert, Walter, Nunez, Jacques, Pfanner, Nikolaus   +3 more
core   +4 more sources

Fetal Membranes Contribute to Drug Transport across the Feto-Maternal Interface Utilizing the Breast Cancer Resistance Protein (BCRP)

Life, 2022
During pregnancy, the placenta is established as a primary organ for drug transport at the maternal-fetal interface. The fetal membranes (FM) also form an interface with maternal tissues; however, their role in drug transport has not been previously ...
Ananthkumar Kammala, Meagan Benson, Esha Ganguly, Enkhtuya Radnaa, Talar Kechichian, Lauren Richardson, Ramkumar Menon   +6 more
doaj   +1 more source

Transport Proteins Enabling Plant Photorespiratory Metabolism

Plants, 2021
Photorespiration (PR) is a metabolic repair pathway that acts in oxygenic photosynthetic organisms to degrade a toxic product of oxygen fixation generated by the enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase. Within the metabolic pathway, energy
Franziska Kuhnert, Urte Schlüter, Nicole Linka, Marion Eisenhut   +3 more
doaj   +1 more source

Development of a Molecular Recognition Electrode and Investigation of a Biomolecular Application in Non-Aqueous Media —Electrochemical Detection of Uremia-Related Substances Excreted via ATP-Binding Cassette Transporter G2—

Electrochemistry, 2021
Detection methods for small biological molecules are needed to facilitate analysis of physiological and pathological mechanisms. We aimed to construct a 2-mercaptobenzimidazole modified gold nanoparticle electrode for detection of uremia-related ...
Kyoko FUJITA, Misaki SEKIDO, Kohei KANNO, Kio HATAE, Kimiyoshi ICHIDA   +4 more
doaj   +1 more source

A large-scale genetic correlation scan between rheumatoid arthritis and human plasma protein

Bone & Joint Research, 2022
Aims The aim of this study was to explore the genetic correlation and causal relationship between blood plasma proteins and rheumatoid arthritis (RA).
Pan Luo, Shiqiang Cheng, Feng Zhang, Ruoyang Feng, Ke Xu, Wensen Jing, Peng Xu   +6 more
doaj   +1 more source

Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei

Scientific Reports, 2021
Trichoderma reesei is an ascomycete fungus known for its capability to secrete high amounts of extracellular cellulose- and hemicellulose-degrading enzymes. These enzymes are utilized in the production of second-generation biofuels and T.
Sami Havukainen, Jonai Pujol-Giménez, Mari Valkonen, Ann Westerholm-Parvinen, Matthias A. Hediger, Christopher P. Landowski   +5 more
doaj   +1 more source

ET-MSF: a model stacking framework to identify electron transport proteins

Frontiers in Bioscience-Landmark, 2022
Introduction: The electron transport chain is closely related to cellular respiration and has been implicated in various human diseases. However, the traditional “wet” experimental method is time consuming.
Yizheng Wang, Qingfeng Pan, Xiaobin Liu, Yijie Ding   +3 more
doaj   +1 more source

PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations

Pharmaceuticals, 2022
Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with ‘de novo’ ability to transport drugs away from their site of action. The PfMDR1 transporter (or P-glycoprotein 1)
Nina Simon, Cornelia Voigtländer, Barbara Kappes, Petra Rohrbach, Oliver Friedrich   +4 more
doaj   +1 more source

Cloning, Amplified Expression and Bioinformatics Analysis of a Putative Nucleobase Cation Symporter-1 (NCS-1) Protein Obtained from Rhodococcus erythropolis

Bioscientific Review, 2021
The Rhodococcus erythropolis gene DYC18_RS18060 (1437 bp) putatively codes for a secondary transporter of the Nucleobase Cation Symporter-1 (NCS-1) protein family (478 amino acids). The DYC18_RS18060 gene was successfully cloned from R.
Irshad Ahmad, Youri Lee, Nighat Nawaz, Rizwan Elahi, Israr Ali Khan, Muhammad Zahid Mustafa, Simon G Patching   +6 more
doaj   +1 more source

Novel Evolutionary Engineering Approach to Alter Substrate Specificity of Disaccharide Transporter Mal11 in Saccharomyces cerevisiae

Journal of Fungi, 2022
A major challenge in the research of transport proteins is to understand how single amino acid residues contribute to their structure and biological function.
Sophie Claire de Valk, Robert Mans
doaj   +1 more source