Results 111 to 120 of about 1,762,603 (292)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cluster production within transport theory

EPJ Web of Conferences, 2016
Clusters are quite important at various situations in heavy-ion collisions and in excited low-density nuclear matter. Antisymmetrized molecular dynamics has been improved to take into account the correlations to form light clusters such as deuterons and ...
Ono Akira
doaj   +1 more source

A multi-agent-based approach for the impacts analysis of passenger flow on platforms in metro stations considering train operations

Transport, 2018
Impacts analysis of train operation on passenger flow in metro stations is an important and fundamental requirement to improve the operational efficiency and ensure passengers a high level of service.
Shaokuan Chen, Yanan Zhang, Yue Di, Fang Li, Wenzheng Jia   +4 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Modeling a HCR Gear with Variable Thickness of the Thin Hard Coating on the Tooth Surface for Fem Analysis

Journal of Mechanical Engineering
This work presents a computer model of HCR gear wheels with thin hard coatings of variable thickness. The coating thickness fluctuates along tooth depth due to limited technological space, particularly at the dedendum.
Protasov Roman, Danko Ján, Ustynenko Oleksandr, Soprunov Igor, Bondarenko Oleksij, Klochkov Illia, Marchenko Yevhenii   +6 more
doaj   +1 more source

Asphalt pavement rutting depth prediction based on FGM(1, 1│sin) model

Nantong Daxue xuebao. Ziran kexue ban
With the rapid development of urban transportation, pavement performance is directly related to the safety of transportation and environmental protection. To effectively model the rutting depth of asphalt pavements this study is based on the FGM(1, 1│sin)
CHEN Yifan; LI Zhuoxuan; CAO Jinde
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Data Source Importance Evaluation for Highway Networks: A Complex Network-Based Approach

Promet (Zagreb)
Data collection technologies or data sources are critical for highway network management. However, due to the limitations on available management resources, determining the importance of these data sources is necessary to allocate these resources ...
Huangqin HUANG, Jianhua GUO, Xiangyu SHI, Leixiao SHEN   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pavement structure optimization design system based on network attack detection and heuristic algorithm

Nantong Daxue xuebao. Ziran kexue ban
To address the practical requirements of asphalt pavement structural design in the current era, a pavement structure optimization design system is designed leveraging deep learning and heuristic algorithms.
ZHANG Jiujiu; SHI Xinli; CAO Jinde
doaj   +1 more source