Results 111 to 120 of about 1,761,291 (295)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enabling Service Level Agreement-Differentiated Protection in C+L Multiband Optical Networks

IEEE Open Journal of the Communications Society
Band division multiplexing (BDM) is a promising technology to upgrade the capacity of elastic optical networks (EON). By using both C and L bands instead of just the C-band, networks can support a larger number of connections.
Soheil Hosseini, Ignacio De Miguel, Noemi Merayo, Oscar Gonzalez De Dios, Ruben M. Lorenzo, Ramon J. Duran Barroso   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Cluster production within transport theory

EPJ Web of Conferences, 2016
Clusters are quite important at various situations in heavy-ion collisions and in excited low-density nuclear matter. Antisymmetrized molecular dynamics has been improved to take into account the correlations to form light clusters such as deuterons and ...
Ono Akira
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Modeling a HCR Gear with Variable Thickness of the Thin Hard Coating on the Tooth Surface for Fem Analysis

Journal of Mechanical Engineering
This work presents a computer model of HCR gear wheels with thin hard coatings of variable thickness. The coating thickness fluctuates along tooth depth due to limited technological space, particularly at the dedendum.
Protasov Roman, Danko Ján, Ustynenko Oleksandr, Soprunov Igor, Bondarenko Oleksij, Klochkov Illia, Marchenko Yevhenii   +6 more
doaj   +1 more source

Asphalt pavement rutting depth prediction based on FGM(1, 1│sin) model

Nantong Daxue xuebao. Ziran kexue ban
With the rapid development of urban transportation, pavement performance is directly related to the safety of transportation and environmental protection. To effectively model the rutting depth of asphalt pavements this study is based on the FGM(1, 1│sin)
CHEN Yifan; LI Zhuoxuan; CAO Jinde
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Data Source Importance Evaluation for Highway Networks: A Complex Network-Based Approach

Promet (Zagreb)
Data collection technologies or data sources are critical for highway network management. However, due to the limitations on available management resources, determining the importance of these data sources is necessary to allocate these resources ...
Huangqin HUANG, Jianhua GUO, Xiangyu SHI, Leixiao SHEN   +3 more
doaj   +1 more source