Results 221 to 230 of about 1,038,949 (301)

EAL 335 TRAFFIC AND TRANSPORTATION ENGINEERING (JUN 2016) [PDF]

, 2016
PPKAW, Pusat Pengajian Kejuruteraan Awam
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Developing Scenario-Based Strategies for Health, Climate, and Environmental Preparedness: The One Health, One Earth Approach. [PDF]

Geohealth
Abadi AM, Brumfield KD, Usmani M, Jiang G, Chakraborty TC, Wang Y, Zhou Z, He C, Qiu M, Stowell JD, Fritz D, Kumar S, Guo Q, Xiong Y, Destouni G, Xiao Q, Hu XC, Fong KC, Hang Y, Nielsen-Gammon J, Habre R, Bratburd JR, Tessum CW, Jutla A, Colwell RR, Filippelli GM, Nguyen TH.   +26 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

An automated decision making framework for modern vehicles CO₂ emissions using multi modal engine telemetry and feature interpretability. [PDF]

Sci Rep
Saraswat SK, Abdullah M, Habelalmateen MI, Vivek V, Sahu PK, Pant R, Sharma S, Shojonov M, Madaminov B.   +8 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A spatio-temporal self-supervised meta-learning network with dynamic graph learning for traffic flow forecasting. [PDF]

PLoS One
Qiu Q, Huang Y, Huang X, Zhou W.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Balancing energy resilience and mobility: a multi-objective strategy for deploying shared autonomous electric vehicles during power outages. [PDF]

NPJ Sustain Mobil Transp
Augusto Manzolli J, Yu J, D'Apice AV, Miranda-Moreno L.   +3 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source