Results 131 to 140 of about 166,559,933 (303)

Connecticut, on the move : strategic long-range transportation plan, 2009-2035; Draft strategic long-range transportation plan, 2009-2035

, 2009
Draft.; Title from PDF cover (viewed May 6, 2009).; Previously published: Long-range transportation plan for the State of Connecticut, 2004-2030. [Newington, Conn.] : Connecticut Dept. of Transportation, [2004]
Connecticut. Dept. of Transportation.
core   +1 more source

Frequency and Risk of Emergency Medical Service Interhospital Transportation of Patients With Acute Lower Respiratory Tract Illness During the COVID-19 Pandemic in the US.

JAMA, 2022
Sarzynski SH, Mancera A, Mann C, Dai M, Sun J, Warner S, Kadri SS.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Other title: Kansas Department of Transportation Works Hard to Make Transportation Work For You

, 2005
application/pdf "February 16, 2005." Testimony before the Kansas Legislature, House Revenue, Judicial, Transportation and Retirement Budget Committee, by staff of the Kansas Department of Transportation.Presentation providing a detailed overview of the ...
Kansas. Department of Transportation.
core  

Federal, State, and Local Transportation Financial Statistics: Fiscal Years 1982\u20131994

This report identifies financial trends of federal, state, and local government transportation-related program revenues and expenditures. Revenues and budget expenditures are displayed for all government transportation-related programs, including ...
United States. Department of Transportation. Research and Special Programs Administration, Sen, B., John A. Volpe National Transportation Systems Center (U.S.)   +2 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Bay Area transportation : state of the system 2002

The Metropolitan Transportation Commission (MTC) and Caltrans District 4 have engaged in a collaborative effort to assemble key facts and performance indicators of interest to Bay Area commuters and other travelers.
California. Metropolitan Transportation Commission, California. Dept. of Transportation. District 4   +1 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Prehospital time intervals for trauma patients according to population density levels in Sweden; a national retrospective cohort study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Minimising time from injury to hospital admission is considered a key factor in trauma. Trauma care is often centralised to hospitals, which, because of their urban location, make treatment more accessible to patients in densely populated ...
Oscar H. M. Lundberg, Oscar Lapidus, Denise Bäckström   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source